Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease

被引：73

作者：

Duarte, Audrey

Hayasaka, Satoru

Du, Antao

Schuff, Norbert

Jahng, Geon-Ho

Kramer, Joel

Miller, Bruce

Weiner, Michael

机构：

[1] San Francisco VA Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Memory & Aging Ctr, San Francisco, CA 94143 USA

来源：

NEUROSCIENCE LETTERS | 2006年 / 406卷 / 1-2期

关键词：

mild cognitive impairment; Alzheimer's; correlation; volumetry; memory; executive;

D O I：

10.1016/j.neulet.2006.07.029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In Alzheimer's disease (AD), atrophy negatively impacts cognition while in healthy adults, inverse relationships between brain volume and cognition may occur. We investigated correlations between gray matter volume and cognition in elderly controls, AD and mild cognitive impairment (MCI) patients with memory and executive deficits. AD demonstrated substantial loss in temporal, parietal and frontal regions while MCI exhibited moderate volume loss in temporal and frontal regions. In controls, memory and executive function were negatively correlated with frontal regions, while in AD, memory was positively correlated with temporal and frontal gyri, and executive function with frontal regions. The combination of the two patterns may explain the lack of correlations in MCI. Developmental versus pathological contributions to these relationships are discussed. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：60 / 65

页数：6

共 27 条

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