Constituents from the fruiting bodies of Ganoderma applanatum and their aldose reductase inhibitory activity

被引：47

作者：

Lee, Sang Hyun

Shim, Sang Hee

Kim, Ju Sun

Kang, Sam Sik ^{[1
]}

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 110460, South Korea

[3] Chung Ang Univ, Coll Ind Sci, Dept Appl Plant Sci, Anseong 456756, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2006年 / 29卷 / 06期

关键词：

Ganoderma applanatum; polyporaceae; ergosterol peroxide; aldose reductase activity;

D O I：

10.1007/BF02969420

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Eight compounds were isolated from the fruiting bodies of Ganoderma applanatum, and were identified as 2-methoxyfatty acids (1), 5-dihydroergosterol (2), ergosterol peroxide (3) 3 beta,7 beta,20,23 xi-tetrahydroxy-11,15-dioxolanosta-8-en-26-oic acid (4), 7 beta,20,23 xi-trihydroxy-3,11,15-trioxolanosta-8-en-26-oic acid (5), cerevisterol (6), 7 beta,23 xi-dihydroxy-3,11,15-trioxolanosta-8,20E(22)-dien-26-oic acid (7), and 7 beta-hydroxy-3,11,15,23-tetraoxolanosta-8,20E(22)-dien-26-oic acid methyl ester (8) by spectral analysis. All compounds were isolated for the first time from this fruiting bodies, and their effect on rat lens aldose reductase (RLAR) activity was tested. Among these eight compounds, ergosterol peroxide (3) was found to exhibit potent RLAR inhibition, its IC50 value being 15.4 mu g/mL.

引用

页码：479 / 483

页数：5

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