Optimum hole-opening condition for cisplatin incorporation in single-wall carbon nanohorns and its release

被引：46

作者：

Ajima, Kumiko

Maigne, Alan

Yudasaka, Masako

Iijima, Sumio

机构：

[1] JST, SORST, NEC, Tsukuba, Ibaraki 3058501, Japan

[2] NEC Corp Ltd, Tsukuba, Ibaraki 3058501, Japan

[3] CNRS, Phys Solides Lab, UMR 8502, F-91405 Orsay, France

[4] Meijo Univ, Tenpaku Ku, Nagoya, Aichi 4688502, Japan

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2006年 / 110卷 / 39期

关键词：

D O I：

10.1021/jp064915x

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We enclosed cisplatin (CDDP), an anticancer drug, inside single-wall carbon nanohorns (SWNH) with holes opened by being heated from room temperature to a target temperature (475-580 degrees C) in flowing dry air, with an increase rate of 1 degrees C/min. The optimum target temperature was found to be 500 degrees C, in terms of the least amount of CDDP deposited outside the SWNH, when the quantity of CDDP encapsulated inside the SWNH was 12 wt %. The incorporated CDDP was slowly released from the SWNH in phosphate buffer saline, and the released quantity was 80%, which was greatly improved from the previous value of 15%. This indicated that a CDDP-containing SWNH could become more potentially useful for biological applications.

引用

收藏

页码：19097 / 19099

页数：3

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