Recovery and rehabilitation in stroke - Stem cells

被引：71

作者：

Lindvall, O

Kokaia, Z

机构：

[1] Univ Hosp, Wallenberg Neurosci Ctr, Sect Restorat Neurol, Lab Neurogenesis & Cell Therapy, SE-22184 Lund, Sweden

[2] Univ Hosp, Stem Cell Inst, Lab Neural Stem Cell Biol, SE-22184 Lund, Sweden

[3] Lund Strateg Res Ctr Stem Cell Biol & Cell Therap, Lund, Sweden

来源：

STROKE | 2004年 / 35卷 / 11期

关键词：

acute care; rehabilitation; stem cells; stem cell transplantation;

D O I：

10.1161/01.STR.0000143323.84008.f4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The recent demostration that neurons for transplantation can be generated from stem cells and that the adult brain produces new neurons in response to stroke has raised hope for the development of a stem cell therapy for patients affected with this disorder. In this review we propose a road map to the clinic and describe the different scientific tasks that need to be accomplished to move stem cell-based approaches toward application in stroke patients.

引用

页码：2691 / 2694

页数：4

共 36 条

[21] Clonal human (hNT) neuron grafts for stroke therapy - Neuropathology in a patient 27 months after implantation [J].

Nelson, PT ;

Kondziolka, D ;

Wechsler, L ;

Goldstein, S ;

Gebel, J ;

DeCesare, S ;

Elder, EM ;

Zhang, PJ ;

Jacobs, A ;

McGrogan, M ;

Lee, VMY ;

Trojanowski, JQ .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 160 (04) :1201-1206

[22] Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain [J].

Nunes, MC ;

Roy, NS ;

Keyoung, HM ;

Goodman, RR ;

McKhann, G ;

Jiang, L ;

Kang, J ;

Nedergaard, M ;

Goldman, SA .

NATURE MEDICINE, 2003, 9 (04) :439-447

[23] A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease [J].

Olanow, CW ;

Goetz, CG ;

Kordower, JH ;

Stoessl, AJ ;

Sossi, V ;

Brin, MF ;

Shannon, KM ;

Nauert, GM ;

Perl, DP ;

Godbold, J ;

Freeman, TB .

ANNALS OF NEUROLOGY, 2003, 54 (03) :403-414

[24]

Palmer TD, 2000, J COMP NEUROL, V425, P479, DOI 10.1002/1096-9861(20001002)425:4<479::AID-CNE2>3.0.CO

[25]

2-3

[26] Rat forebrain neurogenesis and striatal neuron replacement after focal stroke [J].

Parent, JM ;

Vexler, ZS ;

Gong, C ;

Derugin, N ;

Ferriero, DM .

ANNALS OF NEUROLOGY, 2002, 52 (06) :802-813

[27] The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue [J].

Park, KI ;

Teng, YD ;

Snyder, EY .

NATURE BIOTECHNOLOGY, 2002, 20 (11) :1111-1117

[28] Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient [J].

Piccini, P ;

Brooks, DJ ;

Björklund, A ;

Gunn, RN ;

Grasby, PM ;

Rimoldi, O ;

Brundin, P ;

Hagell, P ;

Rehncrona, S ;

Widner, H ;

Lindvall, O .

NATURE NEUROSCIENCE, 1999, 2 (12) :1137-1140

[29]

Piccini P, 2000, ANN NEUROL, V48, P689, DOI 10.1002/1531-8249(200011)48:5<689::AID-ANA1>3.3.CO

[30]

2-E

← 1 2 3 4 →