Damage control: Management of cellular stress by the NLRP3 inflammasome

被引：18

作者：

Haasken, Stefanie ^{[1
]}

Sutterwala, Fayyaz S. ^{[1
,2
]}

机构：

[1] Univ Iowa, Carver Coll Med, Dept Internal Med, Inflammat Program, Coralville, IA 52241 USA

[2] Vet Affairs Med Ctr, Iowa City, IA 52242 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2013年 / 43卷 / 08期

关键词：

Caspase-1; DC; Genotoxic stress; NLRP3; inflammasome; NALP3; INFLAMMASOME; ACTIVATION; CASPASE-1; PATHWAY;

D O I：

10.1002/eji.201343848

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The NLRP3 inflammasome plays a critical role in regulating inflammatory and cell death pathways in response to a diverse array of stimuli. Activation of the NLRP3 inflammasome results in activation of the cysteine protease caspase-1 and the subsequent processing and secretion of the proinflammatory cytokines IL-1 and IL-18. In this issue of the European Journal of Immunology, Licandro et al. [Eur. J. Immunol. 2013. 43, 2126-2137] show that the NLRP3 inflammasome contributes to oxidative DNA damage. In addition, activation of the NLRP3 inflammasome modulates a number of pathways involved in DNA damage repair, cell cycle, and apoptosis, suggesting a novel role for the NLRP3 inflammasome in DNA damage responses following cellular stress.

引用

收藏

页码：2003 / 2005

页数：3

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