Proton pump inhibitors and gastric neoplasia

被引：76

作者：

Kuipers, E. J. ^{[1
]}

机构：

[1] Univ Rotterdam, Med Ctr, Dept Gastroenterol & Hepatol, Erasmus MC, NL-3000 CA Rotterdam, Netherlands

来源：

GUT | 2006年 / 55卷 / 09期

关键词：

D O I：

10.1136/gut.2005.090514

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Proton pump inhibitors (PPIs) are very effective in maintaining symptomatic and endoscopic remission of acid peptic disorders, such as gastro-oesophageal reflux disease. Side effects with respect to function and morphology of the gastric mucosa are common. Helicobacter pylori eradication can partially prevent and reverse these effects without impairing PPI therapy for gastro-oesophageal reflux disease. This makes long term PPI treatment a safe therapy for patients with acid peptic disorders. The potential side effects of such therapy are discussed here.

引用

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页码：1217 / 1221

页数：5

相关论文

共 45 条

[11] High-grade dysplasia in sporadic fundic gland polyps:: a case report and review of the literature [J].

Jalving, M ;

Koornstra, JJ ;

Götz, JM ;

van der Waaij, LA ;

de Jong, S ;

Zwart, N ;

Karrenbeld, A ;

Kleibeuker, JH .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2003, 15 (11) :1229-1233

[12] Dysplasia in fundic gland polyps is associated with nuclear β-catenin expression and relatively high cell turnover rates [J].

Jalving, M ;

Koornstra, JJ ;

Boersma-van Ek, W ;

de Jong, S ;

Karrenbeld, A ;

Hollema, H ;

de Vries, EGE ;

Kleibeuker, JH .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2003, 38 (09) :916-922

[13] Long-term omeprazole treatment in resistant gastroesophageal reflux disease:: Efficacy, safety, and influence on gastric mucosa [J].

Klinkenberg-Knol, EC ;

Nelis, F ;

Dent, J ;

Snel, P ;

Mitchell, B ;

Prichard, P ;

Lloyd, D ;

Havu, N ;

Frame, MH ;

Romàn, J ;

Walan, A .

GASTROENTEROLOGY, 2000, 118 (04) :661-669

[14] LONG-TERM TREATMENT WITH OMEPRAZOLE FOR REFRACTORY REFLUX ESOPHAGITIS - EFFICACY AND SAFETY [J].

KLINKENBERGKNOL, EC ;

FESTEN, HPM ;

JANSEN, JBMJ ;

LAMERS, CBHW ;

NELIS, F ;

SNEL, P ;

LUCKERS, A ;

DEKKERS, CPM ;

HAVU, N ;

MEUWISSEN, M .

ANNALS OF INTERNAL MEDICINE, 1994, 121 (03) :161-167

[15] Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease:: results of a randomised controlled trial [J].

Kuipers, EJ ;

Nelis, GF ;

Klinkenberg-Knol, EC ;

Snel, P ;

Goldfain, D ;

Kolkman, JJ ;

Festen, HPM ;

Dent, J ;

Zeitoun, P ;

Havu, N ;

Lamm, M ;

Walan, A .

GUT, 2004, 53 (01) :12-20

[16]

KUIPERS EJ, 1995, ALIMENT PHARM THER, V9, P331

[17]

Kuipers EJ, 2000, GASTROENTEROLOGY, V118, P239, DOI 10.1016/S0016-5085(00)70445-8

[18] Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication [J].

Kuipers, EJ ;

Lundell, L ;

KlinkenbergKnol, EC ;

Havu, N ;

Festen, HPM ;

Liedman, B ;

Lamers, CBHW ;

Jansen, JBMJ ;

Dalenback, J ;

Snel, P ;

Nelis, GF ;

Meuwissen, SGM .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (16) :1018-1022

[19] LONG-TERM OMEPRAZOLE THERAPY IN PEPTIC-ULCER DISEASE - GASTRIN, ENDOCRINE CELL-GROWTH, AND GASTRITIS [J].

LAMBERTS, R ;

CREUTZFELDT, W ;

STRUBER, HG ;

BRUNNER, G ;

SOLCIA, E .

GASTROENTEROLOGY, 1993, 104 (05) :1356-1370

[20] TIME-COURSE OF DEVELOPMENT AND REVERSAL OF GASTRIC ENDOCRINE CELL HYPERPLASIA AFTER INHIBITION OF ACID-SECRETION - STUDIES WITH OMEPRAZOLE AND RANITIDINE IN INTACT AND ANTRECTOMIZED RATS [J].

LARSSON, H ;

CARLSSON, E ;

HAKANSON, R ;

MATTSSON, H ;

NILSSON, G ;

SEENSALU, R ;

WALLMARK, B ;

SUNDLER, F .

GASTROENTEROLOGY, 1988, 95 (06) :1477-1486

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