2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease

被引：53

作者：

Fargo, Keith N. ^{[1
]}

Aisen, Paul ^{[2
]}

Albert, Marilyn ^{[3
]}

Au, Rhoda ^{[4
,5
]}

Corrada, Maria M. ^{[6
,7
]}

DeKosky, Steven ^{[8
,9
,10
]}

Drachman, David ^{[11
]}

Fillit, Howard ^{[12
,13
]}

Gitlin, Laura ^{[14
]}

Haas, Magali ^{[15
]}

Herrup, Karl ^{[16
,17
]}

Kawas, Claudia ^{[18
,19
]}

Khachaturian, Ara S. ^{[20
]}

Khachaturian, Zaven S. ^{[21
]}

Klunk, William ^{[22
]}

Knopman, David ^{[23
]}

Kukull, Walter A. ^{[24
,25
]}

Lamb, Bruce ^{[26
]}

Logsdon, Rebecca G. ^{[27
]}

Maruff, Paul ^{[28
,29
]}

Mesulam, Marsel ^{[30
,31
]}

Mobley, William ^{[2
]}

Mohs, Richard ^{[32
]}

Morgan, David ^{[33
]}

Nixon, Ralph A. ^{[34
,35
,36
]}

Paul, Steven ^{[37
]}

Petersen, Ronald ^{[23
]}

Plassman, Brenda ^{[38
]}

Potter, William ^{[39
]}

Reiman, Eric ^{[40
,41
]}

Reisberg, Barry ^{[42
,43
]}

Sano, Mary

Schindler, Rachel ^{[44
]}

Schneider, Lon S. ^{[45
,46
,47
]}

Snyder, Peter J. ^{[48
,49
]}

Sperling, Reisa A. ^{[50
,51
]}

Yaffe, Kristine ^{[52
,53
,54
]}

Bain, Lisa J.

Thies, William H. ^{[1
]}

Carrillo, Maria C. ^{[1
]}

机构：

[1] Alzheimers Assoc, Div Med & Sci Relat, Chicago, IL 60631 USA

[2] Univ Calif San Diego, Sch Med, Dept Neurosci, San Diego, CA 92103 USA

[3] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA

[4] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[5] Boston Univ, Sch Med, Framingham Heart Study, Boston, MA 02118 USA

[6] Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA

[7] Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA

[8] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[9] Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA

[10] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[11] Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA USA

[12] Icahn Sch Med Mt Sinai, Dept Geriatr & Palliat Med, Alzheimers Drug Discovery Fdn, New York, NY 10029 USA

[13] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA

[14] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD USA

[15] Orion Bionetworks, Cambridge, MA USA

[16] Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Hong Kong, Peoples R China

[17] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Kowloon, Hong Kong, Peoples R China

[18] Univ Calif Irvine, Dept Neurobiol & Behav, Dept Neurol, Irvine, CA USA

[19] Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Irvine, CA USA

[20] Natl Biomed Res Eth Council, Rockville, MD USA

[21] PAD2020, Rockville, MD USA

[22] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA

[23] Mayo Clin, Coll Med, Alzheimers Dis Res Ctr, Dept Neurol, Rochester, MN USA

[24] Univ Washington, NACC, Seattle, WA 98195 USA

[25] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[26] Cleveland Clin, Lerner Res Inst, Dept Neurosci, Cleveland, OH 44106 USA

[27] Univ Washington, Dept Psychosocial & Community Hlth, Seattle, WA 98195 USA

[28] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[29] CogState Ltd, Melbourne, Vic, Australia

[30] Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA

[31] Northwestern Univ, Feinberg Sch Med, Alzheimers Dis Ctr, Chicago, IL 60611 USA

[32] Eli Lilly & Co, Neurosci Early Clin Dev, Indianapolis, IN 46285 USA

[33] Univ S Florida, Byrd Alzheimers Inst, Tampa, FL USA

[34] NYU, Dept Psychiat, Langone Med Ctr, New York, NY 10016 USA

[35] NYU, Dept Cell Biol, Langone Med Ctr, New York, NY 10016 USA

[36] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA

[37] Fdn Natl Inst Hlth, Bethesda, MD USA

[38] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA

[39] Fdn Natl Inst Hlth, Neuroscience Steering Comm Biomarkers Consortium, Phoenix, AZ USA

[40] Univ Arizona, Coll Med, Banner Alzheimers Inst, Phoenix, AZ USA

[41] Univ Arizona, Coll Med, Dept Psychiat, Phoenix, AZ USA

[42] NYU, Sch Med, Dept Psychiat, New York, NY USA

[43] NYU, Sch Med, Alzheimers Dis Res Ctr, New York, NY USA

[44] Pfizer Inc, New York, NY USA

[45] Univ So Calif, Dept Psychiat & Behav Sci, Los Angeles, CA USA

[46] Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA

[47] Univ So Calif, Leonard Davis Sch Gerontol, Los Angeles, CA USA

[48] Brown Univ, Alpert Med Sch, Dept Neurol, Providence, RI 02912 USA

[49] Rhode Isl Hosp, Dept Neurol, Providence, RI USA

[50] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA

来源：

ALZHEIMERS & DEMENTIA | 2014年 / 10卷 / 05期

关键词：

Policy; National Plan to Address Alzheimer's Disease; Milestones; AFRICAN-AMERICANS; HYPOTHETICAL MODEL; DRUG-DEVELOPMENT; DEMENTIA; BIOMARKERS; RECRUITMENT; PREVALENCE; CHALLENGES; DIAGNOSIS;

D O I：

10.1016/j.jalz.2014.08.103

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

With increasing numbers of people with Alzheimer's and other dementias across the globe, many countries have developed national plans to deal with the resulting challenges. In the United States, the National Alzheimer's Project Act, signed into law in 2011, required the creation of such a plan with annual updates thereafter. Pursuant to this, the US Department of Health and Human Services (HHS) released the National Plan to Address Alzheimer's Disease in 2012, including an ambitious research goal of preventing and effectively treating Alzheimer's disease by 2025. To guide investments, activities, and the measurement of progress toward achieving this 2025 goal, in its first annual plan update (2013) HHS also incorporated into the plan a set of short, medium and long-term milestones. HHS further committed to updating these milestones on an ongoing basis to account for progress and setbacks, and emerging opportunities and obstacles. To assist HHS as it updates these milestones, the Alzheimer's Association convened a National Plan Milestone Workgroup consisting of scientific experts representing all areas of Alzheimer's and dementia research. The workgroup evaluated each milestone and made recommendations to ensure that they collectively constitute an adequate work plan for reaching the goal of preventing and effectively treating Alzheimer's by 2025. This report presents these Workgroup recommendations. (C) 2014 The Alzheimer's Association.

引用

页码：S430 / S452

页数：23

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