Amniotic mesenchymal stem cells display neurovascular tropism and aid in the recovery of injured peripheral nerves

被引：44

作者：

Li, YongNan ^{[1
]}

Guo, Longzhe ^{[2
,3
]}

Ahn, Hyun Sook ^{[6
]}

Kim, Moo Hyun ^{[2
,3
]}

Kim, Sung-Whan ^{[2
,3
,4
,5
,7
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 4, Dept Neurol, Harbin, Heilongjiang, Peoples R China

[2] Dong A Univ, Coll Med, Dept Cardiol, Pusan, South Korea

[3] Dong A Univ Hosp, Reg Clin Trial Ctr, Pusan 602715, South Korea

[4] Dong A Univ, Coll Med, Dept Anat & Cell Biol, Pusan, South Korea

[5] Dong A Univ, Coll Med, Mitochondria Hub Regulat Ctr, Pusan, South Korea

[6] Ilsin Christian Hosp, Dept Obstet & Gynecol, Pusan, South Korea

[7] Int St Marys Hosp, Innovat Cell & Gene Therapy Ctr, Inchon, South Korea

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2014年 / 18卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

amniotic stem cells; angiogenesis; cell therapy; engraftment; peripheral nerve; NEURONAL SURVIVAL; DIABETIC-NEUROPATHY; NERVOUS-SYSTEM; REGENERATION; ANGIOGENESIS; ISCHEMIA; REPAIR; AKT; BRAIN;

D O I：

10.1111/jcmm.12249

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Recently, we reported that human amniotic membrane-derived mesenchymal stem cells (AMMs) possess great angiogenic potential. In this study, we determined whether local injection of AMMs ameliorates peripheral neuropathy. AMMs were transplanted into injured sciatic nerves. AMM injection promoted significant recovery of motor nerve conduction velocity and voltage amplitude compared to human adipose-derived mesenchymal stem cells. AMM implantation also augmented blood perfusion and increased intraneural vascularity. Whole-mount fluorescent imaging analysis demonstrated that AMMs exhibited higher engraftment and endothelial incorporation abilities in the sciatic nerve. In addition, the higher expression of pro-angiogenic factors was detected in AMMs injected into the peripheral nerve. Therefore, these data provide novel therapeutic and mechanistic insights into stem cell biology, and AMM transplantation may represent an alternative therapeutic option for treating peripheral neuropathy.

引用

页码：1028 / 1034

页数：7

共 25 条

[1]

Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival [J].