SNAREs and Munc18 in synaptic vesicle fusion

被引：414

作者：

Rizo, J

Südhof, TC

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA

[3] Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dept Mol Genet, Dallas, TX 75390 USA

[4] Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2002年 / 3卷 / 08期

关键词：

D O I：

10.1038/nrn898

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The release of neurotransmitters by Ca2+-triggered synaptic vesicle exocytosis is an exquisitely regulated process that is fundamental for interneuronal communication. This process involves several steps and is controlled by a protein machinery that must prevent release before Ca2+ entry into presynaptic terminals, and yet must rapidly induce release on Ca2+ influx. Extensive studies of the components of this machinery have indicated that SNAREs and Munc18-1 are central proteins for membrane fusion during exocytosis. An increasing amount of information derived from a convergence of structural, physiological and genetic studies is providing important insights into the mechanism of neurotransmitter release.

引用

收藏

页码：641 / 653

页数：13

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