Helicobacter pylori and gastric cancer

被引：109

作者：

Suzuki, Hidekazu ^{[1
]}

Iwasaki, Eisuke ^{[1
]}

Hibi, Toshifumi ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol,Shinjuku Ku, Tokyo 1608582, Japan

来源：

GASTRIC CANCER | 2009年 / 12卷 / 02期

基金：

日本学术振兴会;

关键词：

Gastric cancer; Helicobacter pylori; Eradication; Randomized controlled trial; Gene polymorphism; Food factor; RANDOMIZED CONTROLLED-TRIAL; NUTRITION EPIC-EURGAST; GENE POLYMORPHISMS; ERADICATION THERAPY; ENDOSCOPIC RESECTION; JAPANESE POPULATION; INCREASED RISK; INFECTION; SUSCEPTIBILITY; ASSOCIATION;

D O I：

10.1007/s10120-009-0507-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Helicobacter pylori is now well known as an important pathogen related to the development of gastric cancer. However, some clinicians still doubt the causal association of H. pylori with the development of gastric cancer. To summarize the recent clinical data on the link between H. pylori and gastric cancer, we reviewed related articles published over the past 3 years, after the award of the Nobel Prize for Physiology or Medicine to Drs. J.R. Warren and B.J. Marshall for the first culture and isolation of H. pylori and the investigation of their relevance to peptic ulcer disease. This updated summary of the relationship between H. pylori and gastric cancer highlights the strong link between the organism and the development of gastric cancer, and suggests eradication of this bacterial infection as a possible prophylactic measure against the development of this lethal malignancy. At present, clinicians and researchers in the field emphasize the strong need for H. pylori eradication from the human stomach.

引用

页码：79 / 87

页数：9

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