Dissecting the phenotype in genome-wide association studies of psychiatric illness

被引：48

作者：

Craddock, Nick ^{[1
]}

Kerdler, Kenneth ^{[2
,3
,4
]}

Neale, Michael ^{[2
,3
,4
]}

Nurnberger, John ^{[5
]}

Purcell, Shaun ^{[6
,7
]}

Rietschel, Marcella ^{[8
]}

Perlis, Roy ^{[6
,9
]}

Santangelo, Susan L. ^{[6
,10
,11
]}

Schulze, Thomas ^{[8
,12
]}

Smoller, Jordan W. ^{[6
,10
,11
]}

Thapar, Anita ^{[1
]}

机构：

[1] Cardiff Univ, Sch Med, Dept Psychol Med, Cardiff CF14 4XN, S Glam, Wales

[2] Virginia Commonwealth Univ, Med Coll Virginia, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Med Coll Virginia, Dept Psychiat, Richmond, VA 23298 USA

[4] Virginia Commonwealth Univ, Med Coll Virginia, Dept Human & Mol Genet, Richmond, VA 23298 USA

[5] Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA

[6] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

[7] Harvard & Massachusetts Inst Technol, Broad Inst, Cambridge, MA USA

[8] Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, D-6800 Mannheim, Germany

[9] Massachusetts Gen Hosp, Bipolar Clin & Res Program, Boston, MA 02114 USA

[10] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[11] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[12] NIMH, Unit Genet Basis Mood & Anxiety Disorders, NIH, DHHS, Bethesda, MD 20892 USA

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2009年 / 195卷 / 02期

关键词：

GENETICS; INSIGHTS; LOCI;

D O I：

10.1192/bjp.bp.108.063156

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Over the past 2 years genome-wide association studies have made major contributions to understanding the genetic architecture of many common human diseases. This editorial outlines the development of such studies in psychiatry and highlights the opportunities for advancing understanding of the biological underpinnings and nosological structure of psychiatric disorders.

引用

页码：97 / 99

页数：3

共 19 条

[1] Genetic Mapping in Human Disease [J].

Altshuler, David ;

Daly, Mark J. ;

Lander, Eric S. .

SCIENCE, 2008, 322 (5903) :881-888

[2]

Angst J, 2007, WORLD PSYCHIATRY, V6, P30

[3] A framework for interpreting genome-wide association studies of psychiatric disorders The Psychiatric GWAS Consortium Steering Committee [J].

Cichon, Sven ;

Craddock, Nick ;

Daly, Mark ;

Faraone, Stephen V. ;

Gejman, Pablo V. ;

Kelsoe, John ;

Lehner, Thomas ;

Levinson, Douglas F. ;

Moran, Audra ;

Sklar, Pamela ;

Sullivan, Patrick F. .

MOLECULAR PSYCHIATRY, 2009, 14 (01) :10-17

[4] Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype [J].

Craddock, N. ;

Jones, L. ;

Jones, I. R. ;

Kirov, G. ;

Green, E. K. ;

Grozeva, D. ;

Moskvina, V. ;

Nikolov, I. ;

Hamshere, M. L. ;

Vukcevic, D. ;

Caesar, S. ;

Gordon-Smith, K. ;

Fraser, C. ;

Russell, E. ;

Norton, N. ;

Breen, G. ;

St Clair, D. ;

Collier, D. A. ;

Young, A. H. ;

Ferrier, I. N. ;

Farmer, A. ;

McGuffin, P. ;

Holmans, P. A. ;

Donnelly, P. ;

Owen, M. J. ;

O'Donovan, M. C. .

MOLECULAR PSYCHIATRY, 2010, 15 (02) :146-153

[5]

Craddock N, 2007, WORLD PSYCHIATRY, V6, P20

[6] Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework [J].

Fanous, AH ;

Kendler, KS .

MOLECULAR PSYCHIATRY, 2005, 10 (01) :6-13

[7] Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder [J].

Ferreira, Manuel A. R. ;

O'Donovan, Michael C. ;

Meng, Yan A. ;

Jones, Ian R. ;

Ruderfer, Douglas M. ;

Jones, Lisa ;

Fan, Jinbo ;

Kirov, George ;

Perlis, Roy H. ;

Green, Elaine K. ;

Smoller, Jordan W. ;

Grozeva, Detelina ;

Stone, Jennifer ;

Nikolov, Ivan ;

Chambert, Kimberly ;

Hamshere, Marian L. ;

Nimgaonkar, Vishwajit L. ;

Moskvina, Valentina ;

Thase, Michael E. ;

Caesar, Sian ;

Sachs, Gary S. ;

Franklin, Jennifer ;

Gordon-Smith, Katherine ;

Ardlie, Kristin G. ;

Gabriel, Stacey B. ;

Fraser, Christine ;

Blumenstiel, Brendan ;

Defelice, Matthew ;

Breen, Gerome ;

Gill, Michael ;

Morris, Derek W. ;

Elkin, Amanda ;

Muir, Walter J. ;

McGhee, Kevin A. ;

Williamson, Richard ;

MacIntyre, Donald J. ;

MacLean, Alan W. ;

Clair, David St ;

Robinson, Michelle ;

Van Beck, Margaret ;

Pereira, Ana C. P. ;

Kandaswamy, Radhika ;

McQuillin, Andrew ;

Collier, David A. ;

Bass, Nicholas J. ;

Young, Allan H. ;

Lawrence, Jacob ;

Ferrier, I. Nicol ;

Anjorin, Adebayo ;

Farmer, Anne .

NATURE GENETICS, 2008, 40 (09) :1056-1058

[8] A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity [J].

Frayling, Timothy M. ;

Timpson, Nicholas J. ;

Weedon, Michael N. ;

Zeggini, Eleftheria ;

Freathy, Rachel M. ;

Lindgren, Cecilia M. ;

Perry, John R. B. ;

Elliott, Katherine S. ;

Lango, Hana ;

Rayner, Nigel W. ;

Shields, Beverley ;

Harries, Lorna W. ;

Barrett, Jeffrey C. ;

Ellard, Sian ;

Groves, Christopher J. ;

Knight, Bridget ;

Patch, Ann-Marie ;

Ness, Andrew R. ;

Ebrahim, Shah ;

Lawlor, Debbie A. ;

Ring, Susan M. ;

Ben-Shlomo, Yoav ;

Jarvelin, Marjo-Riitta ;

Sovio, Ulla ;

Bennett, Amanda J. ;

Melzer, David ;

Ferrucci, Luigi ;

Loos, Ruth J. F. ;

Barroso, Ines ;

Wareham, Nicholas J. ;

Karpe, Fredrik ;

Owen, Katharine R. ;

Cardon, Lon R. ;

Walker, Mark ;

Hitman, Graham A. ;

Palmer, Colin N. A. ;

Doney, Alex S. F. ;

Morris, Andrew D. ;

Smith, George Davey ;

Hattersley, Andrew T. ;

McCarthy, Mark I. .

SCIENCE, 2007, 316 (5826) :889-894

[9]

*INT SCHIZ CONS, NATURE IN PRESS

[10] Comparing phenotypes in patients with idiopathic autism to patients with velocardiofacial syndrome (22q11 DS) with and without autism [J].

Kates, Wendy R. ;

Antshel, Kevin M. ;

Fremont, Wanda P. ;

Shprintzen, Robert J. ;

Strunge, Leslie A. ;

Burnette, Courtney P. ;

Higgins, Anne Marie .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2007, 143A (22) :2642-2650

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