Th9 and allergic disease

被引：170

作者：

Soroosh, Pejman ^{[1
]}

Doherty, Taylor A. ^{[1
,2
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Mol Immunol, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

IMMUNOLOGY | 2009年 / 127卷 / 04期

关键词：

airway remodeling; allergy; asthma; IL-9; TGF-beta; Th2; REGULATORY T-CELLS; INTERLEUKIN-9; MESSENGER-RNA; AIRWAY SMOOTH-MUSCLE; GROWTH-FACTOR-BETA; IL-9; EXPRESSION; TGF-BETA; BRONCHIAL HYPERRESPONSIVENESS; TRANSCRIPTION FACTOR; MAST-CELLS; EPITHELIAL-CELLS;

D O I：

10.1111/j.1365-2567.2009.03114.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>Helper CD4(+) T-cell subsets have improved our understanding of adaptive immunity in humans and in animal models of disease. These include T helper type 1 (Th1), Th2 and the interleukin-17 (IL-17) -producing population 'Th17'. Th2 cells have been described as orchestrating the immune response in allergic disease based on studies with patient samples and animal models. The cytokine IL-9 has largely been regarded as a Th2 cytokine that makes multifocal contributions to allergic disease. Recent data suggest that under certain conditions relevant to chronic disease (IL-4 and transforming growth factor-beta), a distinct population of IL-9-producing 'Th9' helper T cells can exist. The contribution of Th9 cells in allergic disease is currently unknown, and this review will propose a model for how these cells may regulate chronic allergic inflammation.

引用

页码：450 / 458

页数：9

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