Influence of superficial organic modification of MCM-41 matrices on drug delivery rate

被引：141

作者：

Horcajada, Patricia

Ramila, Ainhoa

Ferey, Gerard

Vallet-Regi, Maria ^{[1
]}

机构：

[1] UCM, Dept Quim Inorgan & Bioinorgan, Madrid 28040, Spain

[2] Univ Versailles, CNRS, UMR 8637, Inst Lavoisier, F-78035 Versailles, France

来源：

SOLID STATE SCIENCES | 2006年 / 8卷 / 10期

关键词：

MCM-41; mesoporous; surface modification; drug; control release; materials design;

D O I：

10.1016/j.solidstatesciences.2006.04.016

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

MCM-41-type mesoporous materials superficially modified were produced by a post-synthesis method with different organic groups (chloropropyl, phenyl, benzyl, mercaptopropyl, cyanopropyl and butyl groups). A comparative study of the adsorption and release of a model drug, ibuprofen, were carried out. These materials were characterised by XRD, TG, elemental analysis, FTIR, UV, N-2 adsorption and Si-29 and C-13-NMR. The adsorbed drug content and the delivery rate can be chosen according to the host-guest chemical interaction by choosing an adequate modification with an organic group. The specific matrices design for the insertion and delivery of drugs is possible. (c) 2006 Elsevier Masson SAS. All rights reserved.

引用

页码：1243 / 1249

页数：7

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