14′-hydroxymytoxin B and 16-hydroxyroridin E, two new cytotoxic trichothecenes from Myrothecium roridum

被引：24

作者：

Alvi, KA

Rabenstein, J

Woodard, J

Baker, DD

Bergthold, JD

Lynch, J

Lieu, KL

Braude, IA

机构：

[1] Albany Mol Res Inc, Bothell Res Ctr, Bothell, WA 98011 USA

[2] PrimeCyte Inc, Seattle, WA 98109 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 05期

关键词：

D O I：

10.1021/np010449l

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new trichothecenes, 14'-hydroxymytoxin B (1) and 16-hydroxyroridin E (3), were isolated from a fermentation extract of Myrothecium roridum. The structures of I and 3 were determined by spectral data interpretation. Both compounds showed potent cytotoxic activity against primary soft-tissue sarcoma cells.

引用

页码：742 / 744

页数：3

共 17 条

[11] TRICHOVERRITONE AND 16-HYDROXYRORIDIN L-2, NEW TRICHOTHECENES FROM MYROTHECIUM-RORIDUM
JARVIS, BB
VRUDHULA, VM
PAVANASASIVAM, G
[J]. TETRAHEDRON LETTERS, 1983, 24 (34) : 3539 - 3542
[12] JARVIS BB, 1986, B SOC CHIM BELG, V95, P681
[13] ISOLATION AND CHARACTERIZATION OF THE TRICHOVERROIDS AND NEW RORIDINS AND VERRUCARINS
JARVIS, BB
STAHLY, GP
PAVANASASIVAM, G
MIDIWO, JO
DESILVA, T
HOLMLUND, CE
MAZZOLA, EP
GEOGHEGAN, RF
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (06) : 1117 - 1124
[14] Stereochemistry of the roridins. Diastereomers of roridin E
Jarvis, BB
Wang, SJ
[J]. JOURNAL OF NATURAL PRODUCTS, 1999, 62 (09): : 1284 - 1289
[15] Strong FM, 1971, MICROBIAL TOXINS, V7, P207
[16] TAMM C, 1974, FORTSCHR CHEM ORG NA, V31, P61
[17] Ueno Y., 1980, ADV NUTR RES, V3, P301, DOI 10.1007/978-1-4757-4448-4_10

← 1 2 →