Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization

被引：135

作者：

Robinson, Cory M. ^{[1
]}

Sinclair, James F. ^{[1
]}

Smith, Michael J. ^{[1
]}

O'Brien, Alison D. ^{[1
]}

机构：

[1] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 25期

关键词：

adherence; nucleolin;

D O I：

10.1073/pnas.0602359103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Enterohemorrhagic Escherichia coli (EHEC) O157:117 is a food-borne pathogen that can cause bloody diarrhea and, occasionally, acute renal failure as a consequence of Shiga toxin (Stx) production by the organism. Stxs are potent cytotoxins that are lethal to animals at low doses. Thus, Stxs not only harm the host but, as reported here, also significantly enhance the capacity of EHEC O157:117 to adhere to epithelial cells and to colonize the intestines of mice. Tissue culture experiments showed that this toxin-mediated increase in bacterial adherence correlated with an Stx-evoked increase in a eukaryotic receptor for the EHEC O157:117 attachment factor intimin.

引用

页码：9667 / 9672

页数：6

共 28 条

[1] Identification of V3 loop-binding proteins as potential receptors implicated in the binding of HIV particles to CD4+ cells [J].

Callebaut, C ;

Blanco, J ;

Benkirane, N ;

Krust, B ;

Jacotot, E ;

Guichard, G ;

Seddiki, N ;

Svab, J ;

Dam, E ;

Muller, S ;

Briand, JP ;

Hovanessian, AG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (34) :21988-21997

[2] Escherichia coli Shiga-like toxins induce apoptosis and cleavage of poly(ADP-ribose) polymerase via in vitro activation of caspases [J].

Ching, JCY ;

Jones, NL ;

Ceponis, PJM ;

Karmali, MA ;

Sherman, PM .

INFECTION AND IMMUNITY, 2002, 70 (08) :4669-4677

[3] CHARACTERIZATION OF A 100-KILODALTON BINDING-PROTEIN FOR THE 6 SEROTYPES OF COXSACKIE-B VIRUSES [J].

DEVERDUGO, UR ;

SELINKA, HC ;

HUBER, M ;

KRAMER, B ;

KELLERMANN, J ;

HOFSCHNEIDER, PH ;

KANDOLF, R .

JOURNAL OF VIROLOGY, 1995, 69 (11) :6751-6757

[4] AFFINITY PURIFICATION AND CHARACTERIZATION OF SHIGA-LIKE TOXIN-II AND PRODUCTION OF TOXIN-SPECIFIC MONOCLONAL-ANTIBODIES [J].

DOWNES, FP ;

BARRETT, TJ ;

GREEN, JH ;

ALOISIO, CH ;

SPIKA, JS ;

STROCKBINE, NA ;

WACHSMUTH, IK .

INFECTION AND IMMUNITY, 1988, 56 (08) :1926-1933

[5] Identification of Escherichia coli O157:H7 genes influencing colonization of the bovine gastrointestinal tract using signature-tagged mutagenesis [J].

Dziva, F ;

van Diemen, PM ;

Stevens, MP ;

Smith, AJ ;

Wallis, TS .

MICROBIOLOGY-SGM, 2004, 150 :3631-3645

[6]

Gansheroff LJ, 1999, INFECT IMMUN, V67, P6409

[7]

Ginisty H, 1999, J CELL SCI, V112, P761

[8]

Griffin Patricia M., 1995, P739

[9] THE EPIDEMIOLOGY OF INFECTIONS CAUSED BY ESCHERICHIA-COLI O157-H7, OTHER ENTEROHEMORRHAGIC ESCHERICHIA-COLI, AND THE ASSOCIATED HEMOLYTIC UREMIC SYNDROME [J].

GRIFFIN, PM ;

TAUXE, RV .

EPIDEMIOLOGIC REVIEWS, 1991, 13 :60-98

[10] Construction and characterization of an isogenic slt-ii deletion mutant of enterohemorrhagic Escherichia coli [J].

Gunzer, F ;

Bohn, U ;

Fuchs, S ;

Mühldorfer, I ;

Hacker, J ;

Tzipori, S ;

Donohue-Rolfe, A .

INFECTION AND IMMUNITY, 1998, 66 (05) :2337-2341

← 1 2 3 →