Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition

被引：190

作者：

Janin, J ^{[1
]}

机构：

[1] CNRS, Lab Enzymol & Biochim Struct, UPR 9063, F-91198 Gif Sur Yvette, France

来源：

STRUCTURE WITH FOLDING & DESIGN | 1999年 / 7卷 / 12期

关键词：

D O I：

10.1016/S0969-2126(00)88333-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Water molecules are found in abundance in protein-protein and protein-DNA interfaces. Although interface solvent molecules exchange quickly with the bulk solvent, structural and biochemical data suggest that water-mediated interactions are as important as direct hydrogen bonds in the stability and specificity of recognition.

引用

页码：R277 / R279

页数：3

共 21 条

[1] BOUND WATER-MOLECULES AND CONFORMATIONAL STABILIZATION HELP MEDIATE AN ANTIGEN-ANTIBODY ASSOCIATION [J].

BHAT, TN ;

BENTLEY, GA ;

BOULOT, G ;

GREENE, MI ;

TELLO, D ;

DALLACQUA, W ;

SOUCHON, H ;

SCHWARZ, FP ;

MARIUZZA, RA ;

POLJAK, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (03) :1089-1093

[2] Hydration and DNA recognition by homeodomains [J].

Billeter, M ;

Guntert, P ;

Luginbuhl, P ;

Wuthrich, K .

CELL, 1996, 85 (07) :1057-1065

[3] Hydration water molecules seen by NMR and by X-ray crystallography [J].

Billeter, M .

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 1995, 27 :635-645

[4] Anatomy of hot spots in protein interfaces [J].

Bogan, AA ;

Thorn, KS .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 280 (01) :1-9

[5] STRUCTURE OF AN ANTIBODY LYSOZYME COMPLEX UNEXPECTED EFFECT OF A CONSERVATIVE MUTATION [J].

CHACKO, S ;

SILVERTON, E ;

KAMMORGAN, L ;

SMITHGILL, S ;

COHEN, G ;

DAVIES, D .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 245 (03) :261-274

[6] Analysis of protein-protein interactions and the effects of amino acid mutations on their energetics. The importance of water molecules in the binding epitope [J].

Covell, DG ;

Wallqvist, A .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 269 (02) :281-297

[7] A mutational analysis of binding interactions in an antigen-antibody protein-protein complex [J].

Dall'Acqua, W ;

Goldman, ER ;

Lin, WH ;

Teng, C ;

Tsuchiya, D ;

Li, HM ;

Ysern, X ;

Braden, BC ;

Li, YL ;

Smith-Gill, SJ ;

Mariuzza, RA .

BIOCHEMISTRY, 1998, 37 (22) :7981-7991

[8] CRYSTAL AND MOLECULAR-STRUCTURES OF THE COMPLEX OF ALPHA-CHYMOTRYPSIN WITH ITS INHIBITOR TURKEY OVOMUCOID 3RD DOMAIN AT 1.8 A RESOLUTION [J].

FUJINAGA, M ;

SIELECKI, AR ;

READ, RJ ;

ARDELT, W ;

LASKOWSKI, M ;

JAMES, MNG .

JOURNAL OF MOLECULAR BIOLOGY, 1987, 195 (02) :397-418

[9] Analysis of binding interactions in an idiotope-antiidiotope protein-protein complex by double mutant cycles [J].

Goldman, ER ;

DallAcqua, W ;

Braden, BC ;

Mariuzza, RA .

BIOCHEMISTRY, 1997, 36 (01) :49-56

[10] THE DNA TARGET OF THE TRP REPRESSOR [J].

HARAN, TE ;

JOACHIMIAK, A ;

SIGLER, PB .

EMBO JOURNAL, 1992, 11 (08) :3021-3030

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