Expression of cyclin-dependent kinase inhibitor p21(WAF1) and p53 tumour suppressor gene in laryngeal cancer

被引：26

作者：

Jeannon, JP

Soames, J

Lunec, J

Awwad, S

Ashton, V

Wilson, JA

机构：

[1] Univ Newcastle Upon Tyne, Dept Otolaryngol Head & Neck Surg, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Univ Newcastle Upon Tyne, Dept Oral Pathol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[3] Univ Newcastle Upon Tyne, Canc Res Unit, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Univ Teesside, Ctr Hlth & Med Res, Middlesbrough TS1 3BA, Cleveland, England

[5] Royal Hosp, Dept Radiotherapy & Oncol, Shrewsbury, Salop, England

来源：

CLINICAL OTOLARYNGOLOGY | 2000年 / 25卷 / 01期

关键词：

cyclin-dependent kinase inhibitor p21(WAF1); p53 tumour suppressor gene;

D O I：

10.1046/j.1365-2273.2000.00318.x

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The prognostic value of the expression of the cyclin-dependent kinase inhibitor p21 and the p53 tumour suppressor gene was examined using immunohistochemistry in 60 patients with laryngeal cancer. Multivariate analysis using Cox's proportional hazard method, showed that p21 expression (P = 0.02) and advanced T stage (P = 0.003) significantly predicted survival. It was concluded that p21 expression may be a useful prognostic indicator in laryngeal cancer.

引用

页码：23 / 27

页数：5

共 14 条

[1] P53 overexpression in head and neck carcinoma and radiotherapy results [J].

Awwad, S ;

Jaros, E ;

Somes, J ;

Lunec, J .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1996, 34 (02) :323-332

[2]

ELDEIRY WS, 1994, CANCER RES, V54, P1169

[3]

Erber R, 1997, INT J CANCER, V74, P383, DOI 10.1002/(SICI)1097-0215(19970822)74:4<383::AID-IJC4>3.0.CO

[4]

2-R

[5]

Fracchiolla NS, 1997, CANCER-AM CANCER SOC, V79, P1114, DOI 10.1002/(SICI)1097-0142(19970315)79:6<1114::AID-CNCR9>3.3.CO

[6]

2-I

[7] Cyclins, cyclin-dependent kinases, cyclin-dependent kinase inhibitors and their role in head and neck cancer [J].

Jeannon, JP ;

Wilson, JA .

CLINICAL OTOLARYNGOLOGY, 1998, 23 (05) :420-424

[8] The dynamics of cyclin dependent kinase structure [J].

Morgan, DO .

CURRENT OPINION IN CELL BIOLOGY, 1996, 8 (06) :767-772

[9]

Patel V, 1997, INT J CANCER, V73, P551, DOI 10.1002/(SICI)1097-0215(19971114)73:4<551::AID-IJC16>3.0.CO

[10]

2-C

← 1 2 →