Transcriptional control of DNA-based nanomachines

被引：66

作者：

Dittmer, WU

Simmel, FC

机构：

[1] Univ Munich, Sekt Phys, D-80539 Munich, Germany

[2] Univ Munich, Ctr Nanosci, D-80539 Munich, Germany

来源：

NANO LETTERS | 2004年 / 4卷 / 04期

关键词：

D O I：

10.1021/nl049784v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The construction of autonomous DNA-based nanomachines is an important challenge. To this end we have combined DNA tweezers with the transcription machinery of prokaryotic organisms and created a gene that codes for the production of an mRNA strand to bring about a conformational change in the tweezers. Gel electrophoresis and FRET experiments demonstrate that the transcription process successfully reads out the gene and automatically brings the machine to the desired state.

引用

页码：689 / 691

页数：3

共 11 条

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