Runx2 and microRNA regulation in bone and cartilage diseases

被引：31

作者：

Zhao, Weiwei ^{[1
,2
]}

Zhang, Shanxing ^{[1
]}

Wang, Baoli ^{[3
,4
]}

Huang, Jian ^{[1
]}

Lu, William W. ^{[2
]}

Chen, Di ^{[1
]}

机构：

[1] Rush Univ, Med Ctr, Dept Biochem, 1735 West Harrison St, Chicago, IL 60612 USA

[2] Univ Hong Kong, Li Ka Shing Fac Med, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China

[3] Tianjin Med Univ, Metab Dis Hosp, Key Lab Hormone & Dev, Minist Hlth, Tianjin, Peoples R China

[4] Tianjin Med Univ, Tianjin Inst Endocrinol, Tianjin, Peoples R China

来源：

MUSCULOSKELETAL REPAIR AND REGENERATION | 2016年 / 1383卷

基金：

中国国家自然科学基金;

关键词：

Runx2; microRNA; bone; cartilage; HISTONE DEACETYLASE 4; OSTEOARTHRITIS-LIKE PHENOTYPE; ARTICULAR CHONDROCYTES LEADS; TRANSCRIPTION FACTOR RUNX2; SMOOTH-MUSCLE-CELLS; STEM-CELLS; OSTEOGENIC DIFFERENTIATION; OSTEOBLAST DIFFERENTIATION; CONDITIONAL ACTIVATION; PROTEIN EXPRESSION;

D O I：

10.1111/nyas.13206

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The homeostasis of skeletal tissues requires tight regulation of a variety of signaling pathways, and the onset and progression of skeletal diseases are often caused by signaling abnormalities. MicroRNAs (miRNAs) are short noncoding RNA molecules that have emerged as a new dimension of gene regulation. MiRNAs have been shown to play an important role in the regulation of the differentiation of embryonic and hematopoietic stem cells. However, the role of specific miRNAs and their target genes has not been fully defined in the regulation of mesenchymal stem cells. Runx2 is a key transcription factor controlling MSC differentiation and bone and cartilage function. This article reviews work on Runx2 and miRNA regulation in bone and cartilage diseases.

引用

页码：80 / 87

页数：8

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