Correlation between the Size of the Solid Component on Thin-Section CT and the Invasive Component on Pathology in Small Lung Adenocarcinomas Manifesting as Ground-Glass Nodules

被引:319
作者
Lee, Kyung Hee [1 ,2 ]
Goo, Jin Mo [1 ,2 ,3 ]
Park, Sang Joon [1 ,2 ,3 ]
Wi, Jae Yeon [1 ,2 ]
Chung, Doo Hyun [4 ]
Go, Heounjeong [5 ]
Park, Heae Surng [6 ]
Park, Chang Min [1 ,2 ,3 ]
Lee, Sang Min [1 ,2 ]
机构
[1] Seoul Natl Univ, Coll Med, Dept Radiol, Seoul 110744, South Korea
[2] Seoul Natl Univ, Inst Radiat Med, Med Res Ctr, Seoul 110744, South Korea
[3] Seoul Natl Univ, Cencer Res Inst, Seoul 110744, South Korea
[4] Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 110744, South Korea
[5] Asan Med Ctr, Dept Pathol, Seoul, South Korea
[6] Yeonsei Univ, Coll Med, Dept Pathol, Gangnam Severance Hosp, Seoul, South Korea
关键词
Subsolid nodule; Lung adenocarcinoma; Minimally invasive adenocarcinoma; HIGH-RESOLUTION CT; COMPUTED-TOMOGRAPHY; SUBLOBAR RESECTION; PROGNOSTIC-SIGNIFICANCE; CERVICAL-CARCINOMA; CHEST CT; CANCER; CLASSIFICATION; OPACITY; VOLUME;
D O I
10.1097/JTO.0000000000000019
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Introduction: We aimed to evaluate the correlation between the size of the solid component on thin-section computed tomography (CT) and invasive component on pathology in small lung adenocarcinomas manifesting as subsolid nodules. Methods: Fifty-nine subsolid nodules in 58 patients were evaluated. The maximum diameters of subsolid nodules and the solid component on CT were measured by two radiologists in three-dimensional (3D) and two-dimensional (2D) planes using in-house software. In addition, the maximum diameters of the tumor and invasive component were measured on pathology by two pathologists. CT measurements were compared with pathologic measurements. Results: There was a strong correlation between the size of the solid component on CT and invasive component on pathology, as well as the size of subsolid nodules and the tumor size (r = 0.82-0.87 for 3D measurement, 0.72-0.88 for 2D measurement; p < 0.0001). The size of subsolid nodules in 3D and 2D measurements was significantly larger than tumor size (p < 0.0001). In regard to measurement of the solid component, 3D measurements tended to be larger than the size of the invasive component whereas 2D measurement tended to be similar to the size of the invasive component. By applying a size criteria of solid component that was 3 mm or lesser in maximum diameter, preinvasive and minimally invasive adenocarcinoma was predicted with a specificity of 100% (28 of 28). Conclusion: We found a significant correlation between the size of the solid component on thin-section CT and the invasive component on pathology.
引用
收藏
页码:74 / 82
页数:9
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