Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel

被引：48

作者：

Cao, Chunyan

Temel, Yasin

Blokland, Arjan

Ozen, Hatice

Steinbusch, Harry W. M.

Vlamings, Rinske

Nguyen, Huu Phuc

von Hoersten, Stephan

Schmitz, Christoph

Visser-Vandewalle, Veerle

机构：

[1] Univ Hosp Maastricht, EURON, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands

[2] Maastricht Univ, Div Cellular Neurosci, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands

[3] Second Med Univ, Ruijin Hosp, Dept Neurol, Shanghai, Peoples R China

[4] Maastricht Univ, Fac Psychol, Dept Neurocognit, NL-6200 MD Maastricht, Netherlands

[5] Univ Tubingen, Dept Med Genet, D-72076 Tubingen, Germany

[6] Hannover Med Sch, Dept Funct & Appl Anat, D-30625 Hannover, Germany

来源：

BEHAVIOURAL BRAIN RESEARCH | 2006年 / 170卷 / 02期

关键词：

Huntington's disease; transgenic rat; choice reaction time; gene-dose;

D O I：

10.1016/j.bbr.2006.02.028

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We tested the hypothesis that a recently developed transgenic rat model of Huntington's disease (tgHD rats) showed an age-and genotype-dependent change in psychomotor performance and in the frequency of choreiform movements similar to HD patients. Wild type and tgHD (homozygotic and heterozygotic) rats were behaviorally tested at an age of 15 and 20 months. Our results show that tgHD rats exhibit an age-, and genotype-dependent deterioration of the psychomotor performance and choreiform, symptoms, closely mimicking the clinical time course changes of psychomotor symptoms of HD patients. These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD. (c) 2006 Elsevier B.V All rights reserved.

引用

页码：257 / 261

页数：5

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