The permeability transition pore complex in cancer cell death

被引:166
作者
Brenner, C.
Grimm, S.
机构
[1] Univ Versailles, CNRS, FRE 2445, F-78035 Versailles, France
[2] Imperial Coll London, Hammersmith Campus, London W12 0NN, England
基金
英国惠康基金;
关键词
mitochondria; apoptosis; adenine nucleotide translocator; cyclophilin D; VDAC;
D O I
10.1038/sj.onc.1209609
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
The permeability transition pore (PTP) is a multi-protein complex at contact sites of the inner with the outer mitochondrial membrane. Research over the past years has led to the concept that the PTP occupies a central role in cell death induction. Numerous apoptosis signals convert this protein aggregate into an unspecific pore, thus activating mitochondria for the cellular self-destruction process. Here, we describe the evidence for this and the various approaches being undertaken to elucidate its subunit composition and mode of regulation. In particular, we review data that indicate a role of specific PTP subunits for apoptosis inhibition during tumorigenesis.
引用
收藏
页码:4744 / 4756
页数:13
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