An unexpected inhibitory effect of rapamycin against germination of spores of Bacillus brevis strain Nagano

被引：8

作者：

Kim, WS ^{[1
]}

Xu, L ^{[1
]}

Souw, D ^{[1
]}

Fang, AQ ^{[1
]}

Demain, AL ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 07期

关键词：

D O I：

10.7164/antibiotics.55.650

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Rapamycin is used in medicine as an immunosuppressive agent (Sirolimus; Rapamune(TM)) although discovered as an antifungal agent. It is thought not to have antibacterial activity. Surprisingly, we found that rapamycin inhibits the germination of Bacillus brevis Nagano spores, but is inactive against Bacillus brevis Nagano vegetative cells. Surprisingly rapamycin did not show antimicrobial activity against other Bacillus strains, including other gramicidin S-producing Bacillus brevis strains such as ATCC 9999 and BI-7, whether tested as spores or vegetative cells.

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页码：650 / 654

页数：5

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