Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin

被引：37

作者：

Fang, AQ ^{[1
]}

Wong, GK ^{[1
]}

Demain, AL ^{[1
]}

机构：

[1] MIT, Dept Biol, Fermentat Microbiol Lab, Cambridge, MA 02139 USA

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 02期

关键词：

D O I：

10.7164/antibiotics.53.158

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptomyces hygroscopicus ATCC 29253 produces rapamycin, elaiophylin and nigericin. Although elaiophylin has no activity against Candida albicans ATCC 11651, it markedly enhances rapamycin's antifungal activity. Nigericin has only weak activity on its own but it also enhances rapamycin action. Surprisingly, elaiophylin does not enhance nigericin activity on C. albicans.

引用

页码：158 / 162

页数：5

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