Exogenous shikimic acid stimulates rapamycin biosynthesis in Streptomyces hygroscopicus

被引：20

作者：

Fang, A

Demain, AL

机构：

[1] Fermentation Microbiology Laboratory, Massachusetts Institute of Technology, Cambridge, 02139, MA

来源：

FOLIA MICROBIOLOGICA | 1995年 / 40卷 / 06期

关键词：

D O I：

10.1007/BF02818516

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A chemically defined medium was developed which satisfies the nutritional needs of the Streptomyces hygroscopicus strain producing the immunosuppressant rapamycin. More than a doubling of rapamycin biosynthesis was observed on addition of 57 mmol/L of exogenous shikimate. The previously observed inhibition of the synthesis by phenylalanine was not reversed by shikimate.

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页码：607 / 610

页数：4

相关论文

共 17 条

[1]

Byrne K. M., 1993, DEV IND MICROBIOL, V32, P29

[2] PHOSPHATE, AMMONIUM, MAGNESIUM AND IRON NUTRITION OF STREPTOMYCES-HYGROSCOPICUS WITH RESPECT TO RAPAMYCIN BIOSYNTHESIS [J].

CHENG, YR ;

HAUCK, L ;

DEMAIN, AL .

JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1995, 14 (05) :424-427

[3] EFFECT OF AMINO-ACIDS ON RAPAMYCIN BIOSYNTHESIS BY STREPTOMYCES-HYGROSCOPICUS [J].

CHENG, YR ;

FANG, A ;

DEMAIN, AL .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1995, 43 (06) :1096-1098

[4] ON THE CHEMISTRY AND HIGH-FIELD NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY OF RAPAMYCIN [J].

FINDLAY, JA ;

RADICS, L .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1980, 58 (06) :579-590

[5]

FLOSS HG, 1992, ENVIR SCI R, V44, P77

[6]

HATANAKA H, 1988, Journal of Antibiotics (Tokyo), V41, P1592

[7] FK-506, A NOVEL IMMUNOSUPPRESSANT ISOLATED FROM A STREPTOMYCES .1. FERMENTATION, ISOLATION, AND PHYSICOCHEMICAL AND BIOLOGICAL CHARACTERISTICS [J].

KINO, T ;

HATANAKA, H ;

HASHIMOTO, M ;

NISHIYAMA, M ;

GOTO, T ;

OKUHARA, M ;

KOHSAKA, M ;

AOKI, H ;

IMANAKA, H .

JOURNAL OF ANTIBIOTICS, 1987, 40 (09) :1249-1255

[8] CARBON SOURCE NUTRITION OF RAPAMYCIN BIOSYNTHESIS IN STREPTOMYCES-HYGROSCOPICUS [J].

KOJIMA, I ;

CHENG, YR ;

MOHAN, V ;

DEMAIN, AL .

JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1995, 14 (06) :436-439

[9]

Morris R, 1992, TRANSPLANT REV, V6, P39, DOI 10.1016/S0955-470X(10)80014-X

[10] THE CYCLOHEXANE MOIETY OF RAPAMYCIN IS DERIVED FROM SHIKIMIC ACID IN STREPTOMYCES-HYGROSCOPICUS [J].

PAIVA, NL ;

ROBERTS, MF ;

DEMAIN, AL .

JOURNAL OF INDUSTRIAL MICROBIOLOGY, 1993, 12 (06) :423-428