Highly stereoselective direct aldol reactions catalyzed by a bifunctional chiral diamine

被引：17

作者：

Li, Lei ^{[1
,2
]}

Gou, Shaohua ^{[1
,2
,3
]}

Liu, Fei ^{[1
,2
]}

机构：

[1] Southeast Univ, Pharmaceut Res Ctr, Nanjing 211189, Jiangsu, Peoples R China

[2] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China

[3] Southeast Univ, Jiangsu Prov Hitech Key Lab Biomed Res, Nanjing 211189, Jiangsu, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2014年 / 25卷 / 02期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE SYNTHESIS; UNACTIVATED KETONES; ARYL ALDEHYDES; AQUEOUS-MEDIUM; L-PROLINAMIDE; ORGANOCATALYSTS; WATER; ISATINS; ACETALDEHYDE; DESIGN;

D O I：

10.1016/j.tetasy.2013.11.017

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective organocatalytic direct aldol reactions of ketones with various aldehydes were developed by using chiral 1,2-cyclohexanediamine COACH) based multifunctional ligands via a noncovalent catalysis mechanism. By using a catalyst, we also obtained functionalized 3-alkyl-3-hydroxyindolin-2-ones in high yields and with good to excellent enantioselectivities. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：193 / 197

页数：5

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