Sequence determinants of 3A-mediated resistance to enviroxime in rhinoviruses and enteroviruses

被引：52

作者：

Heinz, BA

Vance, LM

机构：

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 07期

关键词：

D O I：

10.1128/JVI.70.7.4854-4857.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using site-directed mutagenesis of the 3A coding region of rhinovirus 14, se have expanded our analysis of resistance to enviroxime. We have observed that high and low-levels of drug resistance involve two domains within 3A and that the amino acid at position 30 is critical in determining resistance.

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页码：4854 / 4857

页数：4

相关论文

共 17 条

[1] ASSOCIATION OF POLIOVIRAL PROTEINS OF THE P2-GENOMIC REGION WITH THE VIRAL REPLICATION COMPLEX AND VIRUS-INDUCED MEMBRANE SYNTHESIS AS VISUALIZED BY ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMISTRY AND AUTORADIOGRAPHY [J].

BIENZ, K ;

EGGER, D ;

PASAMONTES, L .

VIROLOGY, 1987, 160 (01) :220-226

[2] ROLE OF CYTOPLASMIC MEMBRANES IN POLIOVIRUS BIOSYNTHESIS [J].

CALIGUIRI, LA ;

TAMM, I .

VIROLOGY, 1970, 42 (01) :100-+

[3] HIGH-RESOLUTION EPITOPE MAPPING OF HGH-RECEPTOR INTERACTIONS BY ALANINE-SCANNING MUTAGENESIS [J].

CUNNINGHAM, BC ;

WELLS, JA .

SCIENCE, 1989, 244 (4908) :1081-1085

[4] ROLE OF A VIRAL MEMBRANE POLYPEPTIDE IN STRAND-SPECIFIC INITIATION OF POLIOVIRUS RNA-SYNTHESIS [J].

GIACHETTI, C ;

SEMLER, BL .

JOURNAL OF VIROLOGY, 1991, 65 (05) :2647-2654

[5] CIS-ACTING LESIONS TARGETED TO THE HYDROPHOBIC DOMAIN OF A POLIOVIRUS MEMBRANE-PROTEIN INVOLVED IN RNA REPLICATION [J].

GIACHETTI, C ;

HWANG, SS ;

SEMLER, BL .

JOURNAL OF VIROLOGY, 1992, 66 (10) :6045-6057

[6] THE ANTIVIRAL COMPOUND ENVIROXIME TARGETS THE 3A CODING REGION OF RHINOVIRUS AND POLIOVIRUS [J].

HEINZ, BA ;

VANCE, LM .

JOURNAL OF VIROLOGY, 1995, 69 (07) :4189-4197

[7]

HOPE DA, 1995, 4 INT S POS STRAND R, P62

[8] MUTATIONS IN THE HYDROPHOBIC DOMAIN OF POLIOVIRUS PROTEIN 3AB ABROGATE ITS PERMEABILIZING ACTIVITY [J].

LAMA, J ;

CARRASCO, L .

FEBS LETTERS, 1995, 367 (01) :5-11

[9] A ROLE FOR 3AB PROTEIN IN POLIOVIRUS GENOME REPLICATION [J].

LAMA, J ;

SANZ, MA ;

RODRIGUEZ, PL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (24) :14430-14438

[10] ATP IS REQUIRED FOR INITIATION OF POLIOVIRUS RNA-SYNTHESIS INVITRO - DEMONSTRATION OF TYROSINE-PHOSPHATE LINKAGE BETWEEN INVITRO-SYNTHESIZED RNA AND GENOME-LINKED PROTEIN [J].

MORROW, CD ;

HOCKO, J ;

NAVAB, M ;

DASGUPTA, A .

JOURNAL OF VIROLOGY, 1984, 50 (02) :515-523