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Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C

被引：70
作者：
Storer, RI
Takemoto, T
Jackson, PS
Brown, DS
Baxendale, IR
Ley, SV
机构：
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[2] AstraZeneca, Mereside SK10 4TG, Cheshire, England
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2004年 / 10卷 / 10期
关键词：
aldol reaction; antitumor agents; immobilized reagents; polyketides; polymers;
D O I：
10.1002/chem.200305669
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.
引用
收藏
页码：2529 / 2547
页数：19
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