Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction

被引:100
作者
Desch, A. Nicole [1 ,2 ]
Gibbings, Sophie L. [3 ]
Clambey, Eric T. [4 ]
Janssen, William J. [5 ]
Slansky, Jill E. [1 ,2 ]
Kedl, Ross M. [1 ,2 ]
Henson, Peter M. [1 ,2 ,3 ]
Jakubzick, Claudia [1 ,2 ,3 ]
机构
[1] Natl Jewish Hlth, Integrated Dept Immunol, Denver, CO 80206 USA
[2] UC Denver Anschutz Campus, Denver, CO 80206 USA
[3] Natl Jewish Hlth, Dept Pediat, Denver, CO 80206 USA
[4] UC Denver Anschutz Campus, Dept Anesthesiol, Denver, CO 80206 USA
[5] Natl Jewish Hlth, Dept Med, Denver, CO 80206 USA
关键词
MHC CLASS-I; CROSS-PRESENTATION; INFLUENZA-VIRUS; FUNCTIONAL SPECIALIZATIONS; DC SUBSETS; LYMPH-NODE; ANTIGEN; CLEARANCE; RESPONSES; CD4(+);
D O I
10.1038/ncomms5674
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Dendritic cells (DCs) are required for the induction of cytotoxic T cells (CTL). In most tissues, including the lung, the resident DCs fall into two types expressing the integrin markers CD103 and CD11b. The current supposition is that DC function is predetermined by lineage, designating the CD103(+) DC as the major cross-presenting DC able to induce CTL. Here we show that Poly I:C (TLR3 agonist) or R848 (TLR7 agonist) do not activate all endogenous DCs. CD11b(+) DCs can orchestrate a CTL response in vivo in the presence of a TLR7 agonist but not a TLR3 agonist, whereas CD103(+) DCs require ligation of TLR3 for this purpose. This selectivity does not extend to antigen cross-presentation for T-cell proliferation but is required for induction of cytotoxicity. Thus, we demonstrate that the ability of DCs to induce functional CTLs is specific to the nature of the pathogen-associated molecular pattern (PAMP) encountered by endogenous DC.
引用
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页数:12
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