Antibacterial activity of pure flavonoids isolated from mosses

被引:225
作者
Basile, A
Giordano, S
López-Sáez, JA
Cobianchi, RC
机构
[1] Univ Naples Federico II, Dipartimento Biol Vegetale, I-80139 Naples, Italy
[2] CSIC, Ctr Estudios Hist, Lab Arqueobot, E-28014 Madrid, Spain
关键词
mosses; flavonoids; biflavonoids; antibacterial activity; MIC;
D O I
10.1016/S0031-9422(99)00286-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Seven pure flavonoids were isolated and identified from five moss species. The flavonoids were the flavones apigenin, apigenin-7-O-triglycoside, lucenin-2, luteolin-7-O-neohesperidoside, saponarine and vitexin; and the biflavonoid bartramiaflavone. Some of these flavonoids were shown to have pronounced antibacterial effects against Enterobacter cloaceae, E. aerogenes and Pseudomonas aeruginosa (minimal bacteriostatic concentration MIC in the range of 4-2048 mu g/ml). Because of their antibacterial spectrum mainly active against Gram negative bacterial strains, responsible for severe opportunistic infections and resistant to common antibacterial therapy, these flavonoids may be important tools in antibacterial strategies. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1479 / 1482
页数:4
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