Zn(II)/amine-catalyzed coupling reaction of alkylidenemalonates with propargyl alcohol: A one-pot synthesis of methylenetetrahydrofurans

被引：59

作者：

Nakamura, M ^{[1
]}

Liang, CG

Nakamura, E

机构：

[1] Univ Tokyo, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

[2] Japan Sci & Technol Agcy, PRESTO, Saitama 3320012, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 12期

关键词：

D O I：

10.1021/ol0493554

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-catalyzed tandem 1,4-addition/cyclization between propargyl alcohol and a Michael acceptor, such as alkylidene malonate, has been developed. In the presence of catalytic amounts of zinc triflate [Zn(OTf)(2)] and triethylamine (Et3N), various 2-alkylidene-1,3-dicarbonyl compounds reacted with propargyl alcohol to give 3- or 4-methylene tetrahydrofurans in excellent yields.

引用

页码：2015 / 2017

页数：3

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