An in situ approach for nickel-catalyzed cycloaddition

被引：69

作者：

Tekavec, Thomas N. ^{[1
]}

Zuo, Gang ^{[1
]}

Simon, Kristina ^{[1
]}

Louie, Janis ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 15期

关键词：

D O I：

10.1021/jo0608669

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for preparing pyridines from air-stable, commercially available catalyst precursors is described. The addition of n-BuLi to Ni(acac)(2) and an NHC salt (such as IPr center dot HCl or SIPr center dot HCl) rapidly generates an active Ni(0)/NHC catalyst for the cycloaddition of diynes and nitriles that affords pyridines without a decrease in observed yields. The in situ method also converts diynes and carbon dioxide to the corresponding pyrones.

引用

页码：5834 / 5836

页数：3

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