Neuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathway

被引：25

作者：

Amuti, Siyiti ^{[2
]}

Tang, Yuchun ^{[3
]}

Wu, Shuang ^{[2
]}

Liu, Lifen ^{[2
]}

Huang, Liang ^{[2
]}

Zhang, Haibo ^{[2
]}

Li, Huanhuan ^{[2
]}

Jiang, Fen ^{[2
]}

Wang, Geying ^{[1
]}

Liu, Xiaoqing ^{[2
]}

Yuan, Qionglan ^{[1
,2
]}

机构：

[1] Tongji Univ, Shanghai Tongji Hosp, Dept Neurol, Sch Med, Shanghai 200065, Peoples R China

[2] Tongji Univ, Sch Med, Dept Anat & Neurobiol, Shanghai 200092, Peoples R China

[3] Shandong Univ, Res Ctr Sect & Imaging Anat, Sch Med, Jinan 250012, Shandong, Peoples R China

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2016年 / 127卷

基金：

中国国家自然科学基金;

关键词：

Neuroplastin; 65; Learning and memory; Anxiety behaviors; Synaptic plasticity; LONG-TERM POTENTIATION; DENDRITIC SPINES; SPATIAL MEMORY; IMMUNOGLOBULIN SUPERFAMILY; HIPPOCAMPAL-NEURONS; EXPRESSION; BRAIN; RATS; IMPAIRS; GP65;

D O I：

10.1016/j.nlm.2015.11.020

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

Neuroplastin 65 (NP65) is a brain-specific glycoprotein component of synaptic membrane, which is predominantly located in the forebrain such as the cortex, amygdala and striatum and hippocampus. Previous studies have shown that NP65 is implicated in synaptic plasticity, so it was hypothesized to play roles in cognitive functions. To test this hypothesis, we generated NP65 knock-out (KO) mice and found that the null mice exhibited enhanced hippocampus-dependent learning and memory as manifested by Morris water maze test and step-through passive avoidance test, but showed anxiety-like behaviors as manifested by open field test and light/dark exploration test. In addition, molecular and cellular studies revealed several alterations including: (1) the enhanced ratio of excitatory to inhibitory synapses; (2) increased expression of NMDA receptors NR2A; (3) enhanced activation of ERK signaling; (4) lowered number of the mushroom- and bifurcate-shaped dendritic spines in NP65 KO mice. Together, our findings suggest that NP65 may mediate cognitive functions. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：72 / 83

页数：12

共 47 条

[1]

Balancing structure and function at hippocampal dendritic spines [J].

Bourne, Jennifer N. ;

Harris, Kristen M. .

ANNUAL REVIEW OF NEUROSCIENCE, 2008, 31 :47-67

[2]

Development and regulation of dendritic spine synapses [J].

Calabrese, B ;

Wilson, MS ;

Halpain, S .

PHYSIOLOGY, 2006, 21 :38-47

[3]

Cranial Irradiation Alters Dendritic Spine Density and Morphology in the Hippocampus [J].

Chakraborti, Ayanabha ;

Allen, Antino ;

Allen, Barrett ;

Rosi, Susanna ;

Fike, John R. .

PLOS ONE, 2012, 7 (07)

[4]

A Macaque Model of Mesial Temporal Lobe Epilepsy Induced by Unilateral Intrahippocampal Injection of Kainic Acid [J].

Chen, Ning ;

Liu, Chong ;

Yan, Na ;

Hu, Wei ;

Zhang, Jian-guo ;

Ge, Yan ;

Meng, Fan-gang .

PLOS ONE, 2013, 8 (08)

[5]

NEUROPHARMACOLOGIC SPECIFICITY OF A SIMPLE ANIMAL-MODEL FOR THE BEHAVIORAL ACTIONS OF BENZODIAZEPINES [J].

CRAWLEY, JN .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1981, 15 (05) :695-699

[6]

Mitogen-activated protein kinase/extracellular regulated kinase signalling and memory stabilization: a review [J].

Davis, S ;

Laroche, S .

GENES BRAIN AND BEHAVIOR, 2006, 5 :61-72

[7]

Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain [J].

Deng, Wei ;

Saxe, Michael D. ;

Gallina, Iryna S. ;

Gage, Fred H. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (43) :13532-13542

[8]

Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents [J].

Desrivieres, S. ;

Lourdusamy, A. ;

Tao, C. ;

Toro, R. ;

Jia, T. ;

Loth, E. ;

Medina, L. M. ;

Kepa, A. ;

Fernandes, A. ;

Ruggeri, B. ;

Carvalho, F. M. ;

Cocks, G. ;

Banaschewski, T. ;

Barker, G. J. ;

Bokde, A. L. W. ;

Buechel, C. ;

Conrod, P. J. ;

Flor, H. ;

Heinz, A. ;

Gallinat, J. ;

Garavan, H. ;

Gowland, P. ;

Bruehl, R. ;

Lawrence, C. ;

Mann, K. ;

Martinot, M. L. P. ;

Nees, F. ;

Lathrop, M. ;

Poline, J-B ;

Rietschel, M. ;

Thompson, P. ;

Fauth-Buehler, M. ;

Smolka, M. N. ;

Pausova, Z. ;

Paus, T. ;

Feng, J. ;

Schumann, G. .

MOLECULAR PSYCHIATRY, 2015, 20 (02) :263-274

[9]

PSD-95 is required for activity-driven synapse stabilization [J].

Ehrlich, Ingrid ;

Klein, Matthew ;

Rumpel, Simon ;

Malinow, Roberto .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (10) :4176-4181

[10]

The cell adhesion molecule neuroplastin-65 inhibits hippocampal long-term potentiation via a mitogen-activated protein kinase p38-dependent reduction in surface expression of GluR1-containing glutamate receptors [J].

Empson, Ruth M. ;

Buckby, Lucy E. ;

Kraus, Michaela ;

Bates, Katharine J. ;

Crompton, Mark R. ;

Gundelfinger, Eckart D. ;

Beesley, Philip W. .

JOURNAL OF NEUROCHEMISTRY, 2006, 99 (03) :850-860

← 1 2 3 4 5 →