Genetic screening of infertile men

被引：12

作者：

Cram, D

Lynch, M

O'Bryan, MK

Salvado, C

McLachlan, RI

de Kretser, DM

机构：

[1] Monash Univ, Monash Inst Reprod & Dev, Clayton, Vic, Australia

[2] Epworth Med Fdn, Monash IVF, Melbourne, Vic, Australia

[3] Monash Med Ctr, Dept Obstet & Gynaecol, Prince Henrys Inst Reprod & Dev, Melbourne, Vic, Australia

来源：

REPRODUCTION FERTILITY AND DEVELOPMENT | 2004年 / 16卷 / 05期

关键词：

D O I：

10.1071/RD03097

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Male infertility is an extraordinarily common medical condition, affecting 1 in 20 men. According to the World Health Organization, this condition is now considered to be a complex disease involving physical, genetic and environmental factors. With continuing advances in our understanding of male reproductive physiology and endocrinology, together with the availability of the complete sequence of the human genome and powerful functional genomic techniques, the stage is now set to identify the genes that are essential for spermatogenesis. Given that the process of spermatogenesis, from the germ cell to mature sperm, is complex, the challenge for research is to develop the strategies for identifying new genetic causes of idiopathic male infertility and defining genotypes associated with specific defects in semen parameters and testicular pathologies. Such information will form the basis of new genetic tests that will allow the clinician to make an accurate diagnosis of the male partner and a more informed decision about treatment options for the couple.

引用

收藏

页码：573 / 580

页数：8

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