Are complications less common in deep brain stimulation than in ablative procedures for movement disorders?

被引:87
作者
Blomstedt, Patric [1 ]
Hariz, Marwan I.
机构
[1] Umea Univ Hosp, Dept Neurosurg, SE-90185 Umea, Sweden
[2] Inst Neurol, London WC1N 3BG, England
关键词
deep brain stimulation; complications; thalamotomy; pallidotomy; movement disorders;
D O I
10.1159/000094035
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The side effects and complications of deep brain stimulation (DBS) and ablative lesions for tremor and Parkinson's disease were recorded in 256 procedures (129 DBS and 127 lesions). Perioperative complications (seizures, haemorrhage, confusion) were rare and did not differ between the two groups. The rate of hardware-related complications was 17.8%. In ventral intermediate (Vim) thalamotomies, the rate of side effects was 74.5%, in unilateral Vim-DBS 47.3%, while in 7 bilateral Vim-DBS 13 side effects occurred. Most of the side effects of Vim-DBS were reversible upon switching off, or altering, stimulation parameters. In unilateral pallidotomy, the frequency of side effects was 21.9%, while in bilateral staged pallidotomies it was 33.3%. Eight side effects occurred in 11 procedures with pallidal DBS. In 22 subthalamic nucleus DBS procedures, 23 side effects occurred, of which 8 were psychiatric or cognitive. Unilateral ablative surgery may not harbour more postoperative complications or side effects than DBS. Some of the side effects following lesioning are transient and most but not all DBS side effects are reversible. In the Vim DBS is safer than lesioning, while in the pallidum, unilateral lesions are well tolerated. Copyright (c) 2006 S. Karger AG, Basel.
引用
收藏
页码:72 / 81
页数:10
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