A new cytotoxic cardenolide from the latex of Antiaris toxicaria

被引：14

作者：

Gan, Yu Juan ^{[1
]}

Mei, Wen Li ^{[1
]}

Zhao, You Xing ^{[2
]}

Dai, Hao Fu ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2009年 / 20卷 / 04期

基金：

芬兰科学院; 中国国家自然科学基金;

关键词：

Antiaris toxicaria; Moraceae; Toxicarioside E; Cardenolide; Cytotoxicity; DART POISONS;

D O I：

10.1016/j.cclet.2008.12.043

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A new cardenolide, toxicarioside E (1), was isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceac). Its structure was elucidated on the basis of spectral data and chemical evidence. Compound 1 showed significant cytotoxicity against K562 and SGC-7901 cell lines in vitro by MTT method with the IC50 value of 0.026 and 0.027 mu g/mL, respectively. (C) 2008 Hao Fu Dai. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：450 / 452

页数：3

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