The proteolytic environment of chronic wounds

被引：272

作者：

Yager, DR ^{[1
]}

Nwomeh, BC ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Med Coll Virginia, Plast Surg Res Lab, Richmond, VA 23298 USA

来源：

WOUND REPAIR AND REGENERATION | 1999年 / 7卷 / 06期

关键词：

D O I：

10.1046/j.1524-475X.1999.00433.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A consistent feature of chronic leg and pressure ulcers is chronic inflammation associated with an elevated infiltration of neutrophils. Neutrophils and their proteases have been implicated in mediating the tissue damage associated with a variety of chronic inflammatory diseases. This review discusses our current understanding of the proteolytic enzymes found in chronic wounds and attempts to relate this information to the abundant presence of neutrophils. In addition, the implications that the proteolytic environment may have for current and future treatment strategies of chronic nonhealing wounds are discussed.

引用

页码：433 / 441

页数：9