The small world of the cerebral cortex

被引:1050
作者
Sporns, O [1 ]
Zwi, JD [1 ]
机构
[1] Indiana Univ, Dept Psychol, Bloomington, IN 47405 USA
关键词
network; computional neuro-anatomy; small world; complexity; information;
D O I
10.1385/NI:2:2:145
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
While much information is available on the structural connectivity of the cerebral cortex, especially in the primate, the main organization principles of the connection patterns linking brain areas, columns and individual cells have remained elusive. We attempt to characterize a wide variety of cortical connectivity data sets using a specific set of graph theory methods. We measure global aspects of cortical graphs including the abundance of small structural motifs such as cycles, the degree of local clustering of connections and the average path length. We examine large-scale cortical connection matrices obtained from neuroanatomical data bases, as well as probabilistic connection matrices at the level of small cortical neuronal populations linked by intra-areal and inter-areal connections. All cortical connection matrices examined in this study exhibit "small-world" attributes, characterized by the presence of abundant clustering of connections combined with short average distances between neuronal elements. We discuss the significance of these universal organizational features of cortex in light of functional brain anatomy. Supplementary materials are at www.indiana.edu/similar tocortex/lab.htm.
引用
收藏
页码:145 / 162
页数:18
相关论文
共 49 条
[41]  
Sporns O., 2003, NEUROSCIENCE DATABAS, P171, DOI DOI 10.1007/978-1-4615-1079-6_12
[42]  
Sporns Olaf, 2001, Complexity, V7, P28, DOI 10.1002/cplx.10015
[43]   Exploring complex networks [J].
Strogatz, SH .
NATURE, 2001, 410 (6825) :268-276
[44]   Complexity and coherency: integrating information in the brain [J].
Tononi, G ;
Edelman, GM ;
Sporns, O .
TRENDS IN COGNITIVE SCIENCES, 1998, 2 (12) :474-484
[45]   The brainweb: Phase synchronization and large-scale integration [J].
Varela, F ;
Lachaux, JP ;
Rodriguez, E ;
Martinerie, J .
NATURE REVIEWS NEUROSCIENCE, 2001, 2 (04) :229-239
[46]  
Watts D., 2003, Six Degrees: The Science of a Connected Age
[47]  
WATTS D. J, 1999, SMALL WORLDS
[48]   Collective dynamics of 'small-world' networks [J].
Watts, DJ ;
Strogatz, SH .
NATURE, 1998, 393 (6684) :440-442
[49]   THE ORGANIZATION OF NEURAL SYSTEMS IN THE PRIMATE CEREBRAL-CORTEX [J].
YOUNG, MP .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1993, 252 (1333) :13-+