Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure

被引：77

作者：

Chand, Ashwini L.

Ponnampalam, Anna P.

Harris, Sarah E.

Winship, Ingrid M.

Shelling, Andrew N.

机构：

[1] Univ Auckland, Dept Obstet & Gynaecol, Fac Med & Hlth Sci, Auckland, New Zealand

[2] Univ Auckland, Dept Mol Med & Pathol, Fac Med & Hlth Sci, Auckland, New Zealand

来源：

FERTILITY AND STERILITY | 2006年 / 86卷 / 04期

关键词：

D O I：

10.1016/j.fertnstert.2006.02.107

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Mutational screening of the bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) genes in a population with premature ovarian failure (POF) identified no new mutations. However, three single nucleotide polymorphisms in the BMP15 gene, two in the 5' untranslated region (31T > G and 71C > G) and another in exon 1 (387G > A), were found to be common in both POF and control groups.

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页码：1009 / 1012

页数：4

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