Serine protease mechanism and specificity

被引：1409

作者：

Hedstrom, L ^{[1
]}

机构：

[1] Brandeis Univ, Dept Biochem, Waltham, MA 02454 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 12期

关键词：

D O I：

10.1021/cr000033x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Serine... A review is given on the recent work on the mechanism and specificity of chymotrypsin-like enzymes, with the occassional references to pertinent experiments with subtilisin. Focus is on the expression of specificity during catalysis and strategies for substrate discrimination, emphasizing the chymotrypsin-trypsin-elastase paradigm and including examples from Factor D, alpha lytic protease, and thrombin.

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页码：4501 / 4523

页数：23

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