Effect of zaldaride maleate, an antidiarrheal compound, on 16,16-dimethyl prostaglandin E2-induced intestinal ion secretion in rats

被引：1

作者：

Aikawa, N ^{[1
]}

Karasawa, A ^{[1
]}

Ohmori, K ^{[1
]}

机构：

[1] Kyowa Hakko Kogyo Co Ltd, Pharmaceut Res Inst, Drug Dev Res Labs, Nagaizumi, Shizuoka 4118731, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2000年 / 83卷 / 03期

关键词：

zaldaride maleate; calmodulin; intestinal secretion;

D O I：

10.1254/jjp.83.269

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of zaldaride, a calmodulin inhibitor, on 16,16-dimethyl prostaglandin E-2 (dmPGE(2))induced intestinal ion secretion was investigated in rats. Zaldaride inhibited the dmPGE(2)-induced increase in water content in the colon, but not that in the small intestine. In the colonic mucosa, zaldaride attenuated the dmPGE(2)-induced short-circuit current; however, it did not affect the forskolin or dibutyryl cAMP-induced effect. These results suggest that zaldaride inhibits dmPGE(2)-induced intestinal ion secretion by reducing the activity of Ca2+/calmodulin-dependent adenylate cyclase linked to a receptor, and the colon may be an important site in the action of zaldaride.

引用

页码：269 / 272

页数：4

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