Distribution of rat C5a anaphylatoxin receptor

被引：9

作者：

Akatsu, H

Abe, M

Miwa, T

Tateyama, H

Maeda, S

Okada, N

Kojima, K

Okada, H ^{[1
]}

机构：

[1] Nagoya City Univ, Sch Med, Dept Mol Biol, Aichi 4678601, Japan

[2] Nagoya City Univ, Sch Med, Dept Pathol 2, Aichi 4678601, Japan

[3] Nagoya City Univ, Sch Med, Dept Surg 1, Aichi 4678601, Japan

[4] Fukushimura Hosp, Choju Med Inst, Aichi 4418124, Japan

[5] Fukuoka Univ, Sch Med, Dept Pharmacol, Fukuoka 8100180, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2002年 / 46卷 / 12期

关键词：

C5a receptor (C5aR); lipopolysaccharide (LPS); monocytes/macrophages; Kupffer cell;

D O I：

10.1111/j.1348-0421.2002.tb02774.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anaphylatoxim, complement 5a (C5a), plays a key role in mediating various inflammatory reactions following complement activation. Several investigators have reported that C5a receptor (C5aR) is expressed in non-myeloid cells under certain conditions or in different cell lines. In our study, the abundance of C5aR-positive myeloid cells in rats depended on the organs examined. C5aR was usually expressed at the site of exposure to pathogens, such as in salivary gland or lung, and was up-regulated in liver in the inflammatory state induced by lipopolysaccharide (LPS) administration. Furthermore, the increased expression of C5aR antigen was not accompanied by an increase in C5aR mRNA in Kupffer cells following LPS challenge.

引用

页码：863 / 874

页数：12

共 39 条

[31] Characterization of rat C5a anaphylatoxin receptor (C5aR): cloning of rat C5aR cDNA and study of C5aR expression by rat astrocytes
Sayah, S
Patte, C
Gasque, P
Chan, P
Ischenko, A
Vaudry, H
Fontaine, M
[J]. MOLECULAR BRAIN RESEARCH, 1997, 48 (02): : 215 - 222
[32] Anaphylatoxin C5a receptor mRNA is strongly expressed in Kupffer and stellate cells and weakly in sinusoidal endothelial cells but not in hepatocytes of normal rat liver
Schieferdecker, HL
Rothermel, E
Timmermann, A
Gotze, O
Jungermann, K
[J]. FEBS LETTERS, 1997, 406 (03) : 305 - 309
[33] Schlaf G, 1999, LAB INVEST, V79, P1287
[34] Role of complement in the aetiology of Pick's disease?
Singhrao, SK
Neal, JW
Gasque, P
Morgan, BP
Newman, GR
[J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1996, 55 (05) : 578 - 593
[35] BINDING OF FLUORESCEIN-LABELED ANAPHYLATOXIN-C5A TO HUMAN PERIPHERAL-BLOOD, SPLEEN, AND BONE-MARROW LEUKOCYTES
WERFEL, T
OPPERMANN, M
SCHULZE, M
KRIEGER, G
WEBER, M
GOTZE, O
[J]. BLOOD, 1992, 79 (01) : 152 - 160
[36] EXPRESSION OF THE COMPLEMENT C5A ANAPHYLATOXIN RECEPTOR (C5AR) ON NON-MYELOID CELLS
WETSEL, RA
[J]. IMMUNOLOGY LETTERS, 1995, 44 (2-3) : 183 - 187
[37] Wilmer WA, 1998, J IMMUNOL, V160, P5646
[38] The C5a receptor is expressed by human renal proximal tubular epithelial cells
Zahedi, R
Braun, M
Wetsel, RA
Ault, BH
Khan, A
Welch, TR
Frenzke, M
Davis, AE
[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2000, 121 (02) : 226 - 233
[39] Expression of the anaphylatoxin C5a receptor in non-myeloid cells
Zwirner, J
Fayyazi, A
Götze, O
[J]. MOLECULAR IMMUNOLOGY, 1999, 36 (13-14) : 877 - 884

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