The role of p53-induced apoptosis in cerebral ischemia:: effects of the p53 inhibitor pifithrin α

被引：177

作者：

Leker, RR

Aharonowiz, M

Greig, NH

Ovadia, H

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Hadassah Univ Hosp, Agnes Ginges Ctr Human Neurogenet,Dept Neurol, IL-91120 Jerusalem, Israel

[2] NIA, Neurosci Lab, Gerontol Res Ctr 4F01, Baltimore, MD 21224 USA

来源：

EXPERIMENTAL NEUROLOGY | 2004年 / 187卷 / 02期

关键词：

cerebral ischemia; neuroprotection; animals; p53; apoptosis;

D O I：

10.1016/j.expneurol.2004.01.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

No neuroprotective compounds are clinically available for the treatment of ischemic stroke. The potential salutary effect of pifithrin a, a novel-specific inhibitor of the transcription factor p53, administered 1-6 h following focal reversible cerebral ischemia, was investigated. Studies measuring histological, motor, and behavioral outcomes showed significant improvements in pifithrin a-treated animals. Pifithrin a reduced the number of apoptotic cells in the ischemic brain by inhibiting the binding of p53 to its DNA sites as it reduced the expression of the p53-related gene p21(WAF) without changing the amount of p53 protein itself. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：478 / 486

页数：9

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