Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: Tuning the adjuvant versus immunosuppression activity

被引：103

作者：

Fujio, Masakazu

Wu, Douglass

Garcia-Navarro, Raquel

Ho, David D.

Tsuji, Moriya ^{[1
]}

Wong, Chi-Huey

机构：

[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[2] Scripps Res Inst, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 28期

关键词：

D O I：

10.1021/ja062740z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Introduction of an aromatic group into the fatty acyl chain of α-GalCer modulates the activity and selectivity of IFN-γ/IL-4 secretion through CD1d-mediated activation of NKT cells. Compound 14-16 are more potent than α-Galcer and biased for IFN-γ than for IL-4. These new glycolipids may find use as adjuvants or as antimetastatic agents. Copyright © 2006 American Chemical Society.

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页码：9022 / 9023

页数：2

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