A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127

被引:368
作者
Vosshenrich, Christian A. J.
Garcia-Ojeda, Marcos E.
Samson-Villeger, Sandrine I.
Pasqualetto, Valerie
Enault, Laurence
Goff, Odile Richard-Le
Corcuff, Erwan
Guy-Grand, Delphine
Rocha, Benedita
Cumano, Ana
Rogge, Lars
Ezine, Sophie
Di Santo, James P. [1 ]
机构
[1] Inst Pasteur, INSERM, Unite Cytokines & Dev Lymphoide, U668, F-75724 Paris, France
[2] INSERM, Fac Necker Enfants Malades, U591, F-75015 Paris, France
[3] Inst Pasteur, F-75724 Paris, France
[4] INSERM, Unite Dev Lymphocytes, U668, F-75724 Paris, France
关键词
D O I
10.1038/ni1395
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Natural killer ( NK) cell development is thought to occur in the bone marrow. Here we identify the transcription factor GATA-3 and CD127 ( IL-7R alpha) as molecular markers of a pathway of mouse NK cell development that originates in the thymus. Thymus-derived CD127(+) NK cells repopulated peripheral lymphoid organs, and their homeostasis was strictly dependent on GATA-3 and interleukin 7. The CD127(+) NK cells had a distinct phenotype ( CD11b(Io)CD16(-)CD69(hi)Ly49(Io)) and unusual functional attributes, including reduced cytotoxicity but considerable cytokine production. Those characteristics are reminiscent of human CD56(hi)CD16(-) NK cells, which we found expressed CD127 and had more GATA-3 expression than human CD56(+)CD16(+) NK cells. We propose that bone marrow and thymic NK cell pathways generate distinct mouse NK cells with properties similar to those of the two human CD56 NK cell subsets.
引用
收藏
页码:1217 / 1224
页数:8
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