Inositol 1,4,5-trisphosphatereceptors as signal integrators

被引:359
作者
Patterson, RL [1 ]
Boehning, D
Snyder, SH
机构
[1] Johns Hopkins Univ, John Hopkins Med Sch, Dept Neurosci, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, John Hopkins Med Sch, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, John Hopkins Med Sch, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
关键词
calcium; kinases; scaffold; entry; release; structure; regulation;
D O I
10.1146/annurev.biochem.73.071403.161303
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The inositol 1,4,5 trisphosphate (IP3) receptor (IP3R) is a Ca2+ release channel that responds to the second messenger IP3. Exquisite modulation of intracellular Ca2+ release via IP(3)Rs is achieved by the ability of IP3R to integrate signals from numerous small molecules and proteins including nucleotides, kinases, and phosphatases, as well as nonenzyme proteins. Because the ion conduction pore composes only similar to5% of the IP3R, the great bulk of this large protein contains recognition sites for these substances. Through these regulatory mechanisms, IP3R modulates diverse cellular functions, which include, but are not limited to, contraction/excitation, secretion, gene expression, and cellular growth. We review the unique properties of the IP3R that facilitate cell-type and stimulus-dependent control of function, with special emphasis on protein-binding partners.
引用
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页码:437 / 465
页数:29
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