8-methoxypsoralen cream plus targeted narrowband ultraviolet B for psoriasis

被引:32
作者
Amornpinyokeit, Noppadol [1 ]
Asawanonda, Pravit [1 ]
机构
[1] Chulalongkorn Univ, Dept Med, Div Dermatol, King Chulalongkorn Mem Hosp, Bangkok 10330, Thailand
关键词
8-MOP; psoralen; psoriasis; targeted phototherapy; UVB;
D O I
10.1111/j.1600-0781.2006.00249.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background. Targeted ultraviolet (UV) phototherapy is a recent addition to the therapeutic armamentarium for the treatment of localized psoriasis. Topical psoralens enhance the therapeutic effects of UV-based treatment for various dermatoses, but have never been used in conjunction with targeted UVB. Purpose: To compare the efficacy of targeted narrowband UVB phototherapy (NB-UVB) alone with that of the combination of 0.1% 8-methoxypsoralen cream and targeted NB-UVB phototherapy (8-MOP/NB-UVB) for the treatment of plaque-type psoriasis. Methods: Two areas within the same lesion of stable psoriasis were randomized to receive either targeted NB-UVB alone or 8-MOP/NB-UVB. Fluences of UVB delivered were held constant at four minimal erythema doses. The treatments were continued until lesions cleared or 12 treatments. Follow-ups were done until lesional scores returned to 50% of the baseline values. Results: Ten patients completed this study. Four lesions were cleared by 8-MOP/NB-UVB while three were cleared by NB-UVB alone. The improvement in disease activity as reflected by psoriasis severity index score during treatment was statistically significantly better in the combination group (P = 0.005). Mean remission time of lesions which were cleared by 8-MOP/NB-UVB was 8 weeks while that for lesions that were cleared by NB-UVB alone was 4.67 weeks. Conclusion: We concluded that addition of 0.1% 8-MOP cream to targeted narrowband UVB significantly enhances the therapeutic effects of the light treatment without increasing the incidence of adverse effects.
引用
收藏
页码:285 / 289
页数:5
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