Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

被引：162

作者：

Caruso, Roberta ^{[1
]}

Botti, Elisabetta ^{[2
]}

Sarra, Massimiliano ^{[1
]}

Esposito, Maria ^{[2
]}

Stolfi, Carmine ^{[1
]}

Diluvio, Laura ^{[2
]}

Giustizieri, Maria Laura ^{[2
]}

Pacciani, Valentina ^{[2
]}

Mazzotta, Annamaria ^{[2
]}

Campione, Elena ^{[2
]}

MacDonald, Thomas T. ^{[3
]}

Chimenti, Sergio ^{[2
]}

Pallone, Francesco ^{[1
]}

Costanzo, Antonio ^{[2
]}

Monteleone, Giovanni ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Gastroenterol Unit, Dept Internal Med, Rome, Italy

[2] Univ Roma Tor Vergata, Dermatol Unit, Dept Internal Med, Rome, Italy

[3] Barts & London Queen Marys Sch Med & Dent, Inst Cell & Mol Sci, London, England

来源：

NATURE MEDICINE | 2009年 / 15卷 / 09期

关键词：

INFLAMMATION;

D O I：

10.1038/nm.1995

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.

引用

页码：1013 / 1015

页数：3

共 9 条

[1] Autocrine regulation of IL-21 production in human T lymphocytes
Caprioli, Flavio
Sarra, Massimiliano
Caruso, Roberta
Stolfi, Carmine
Fina, Daniele
Sica, Giuseppe
MacDonald, Thomas T.
Pallone, Francesco
Monteleone, Giovanni
[J]. JOURNAL OF IMMUNOLOGY, 2008, 180 (03) : 1800 - 1807
[2] Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions
Hobbs, RM
Silva-Vargas, V
Groves, R
Watt, FM
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (03) : 503 - 515
[3] A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
Liu, Ying
Helms, Cynthia
Liao, Wilson
Zaba, Lisa C.
Duan, Shenghui
Gardner, Jennifer
Wise, Carol
Miner, Andrew
Malloy, M. J.
Pullinger, Clive R.
Kane, John P.
Saccone, Scott
Worthington, Jane
Bruce, Ian
Kwok, Pui -Yan
Menter, Alan
Krueger, James
Barton, Anne
Saccone, Nancy L.
Bowcock, Anne M.
[J]. PLOS GENETICS, 2008, 4 (04):
[4] Pathogenesis and therapy of psoriasis
Lowes, Michelle A.
Bowcock, Anne M.
Krueger, James G.
[J]. NATURE, 2007, 445 (7130) : 866 - 873
[5] IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation
Ma, Hak-Ling
Liang, Spencer
Li, Jing
Napierata, Lee
Brown, Tom
Benoit, Stephen
Senices, Mayra
Gill, Davinder
Dunussi-Joannopoulos, Kyriaki
Collins, Mary
Nickerson-Nutter, Cheryl
Fouser, Lynette A.
Young, Deborah A.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (02) : 597 - 607
[6] Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses
Monteleone, Giovanni
Pallone, Francesco
MacDonald, Thomas T.
[J]. TRENDS IN IMMUNOLOGY, 2008, 29 (06) : 290 - 294
[7] Extracellular regulated kinase and c-Jun N-terminal kinase are activated in psoriatic involved epidermis
Takahashi, H
Ibe, M
Nakamura, S
Ishida-Yamamoto, A
Hashimoto, Y
Iizuka, H
[J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2002, 30 (02) : 94 - 99
[8] Dermal injection of immunocytes induces psoriasis
WroneSmith, T
Nickoloff, BJ
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (08) : 1878 - 1887
[9] Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Zheng, Yan
Danilenko, Dimitry M.
Valdez, Patricia
Kasman, Ian
Eastham-Anderson, Jeffrey
Wu, Jianfeng
Ouyang, Wenjun
[J]. NATURE, 2007, 445 (7128) : 648 - 651

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