Human natural killer cell deficiencies and susceptibility to infection

被引：249

作者：

Orange, JS

机构：

[1] Harvard Univ, Sch Med, Div Immunol, Childrens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 15期

关键词：

NK cells; primary immunodeficiency; herpesviruses; NK cell deficiency;

D O I：

10.1016/S1286-4579(02)00038-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There are a surprisingly large number of human natural killer (NK) cell deficiency states that provide insight into the role of NK cells in defense against human infectious disease. Many disorders associated with NK cell defects are caused by single gene mutations and, thus, give additional understanding concerning the function of specific molecules in NK cell development and activities. A resounding theme of NK cell deficiencies is susceptibility to herpesviruses, suggesting that unexplained severe herpesviral infection should raise the possibility of an NK cell deficit. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

收藏

页码：1545 / 1558

页数：14

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