The role of BTB domain-containing zinc finger proteins in T cell development and function

被引：48

作者：

Bilic, Ivan ^{[1
]}

Ellmeier, Wilfried ^{[1
]}

机构：

[1] Med Univ Vienna, Inst Immunol, A-1090 Vienna, Austria

来源：

IMMUNOLOGY LETTERS | 2007年 / 108卷 / 01期

基金：

奥地利科学基金会;

关键词：

T cell development; T cell subsets; BTB domain; zinc finger; gene expression; transcriptional regulation; gene knockout;

D O I：

10.1016/j.imlet.2006.09.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell fate specifications during T lymphocyte differentiation result from the orchestrated expression of developmentally regulated genes. Furthermore, epigenetic processes that result in a heritable chromatin structure are required for the maintenance of gene expression programs within cells. More and more is known about the basic mechanisms of T cell development and their diversification into various peripheral T cell subsets. Recent research has begun to provide insight into the interactive network of transcription factors as critical regulators of T lymphocyte differentiation. In the past years several members of the BTB domain-containing family of zinc finger proteins (BTB-ZF) have been described to be important for the development and function of hematopoietic cells, and also to contribute to malignant hematopoiesis. This review will provide a brief overview about the role of BTB-ZF proteins during thymocyte development and T cell function. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1 / 9

页数：9

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